Flavonoid-rich Orange Juice is Associated with Acute Improvements in Cognitive Function in Healthy Middle-aged Males

Overview

Journal Eur J Nutr

Specialty Nutritional Sciences

Date 2015 Aug 18

PMID 26280945

Citations 54

Authors

Mudi H Alharbi

Daniel J Lamport

Georgina F Dodd

Caroline Saunders

Laura Harkness

Laurie T Butler

Jeremy P E Spencer

Affiliations

Soon will be listed here.

Abstract

Purpose: Epidemiological evidence suggests that chronic consumption of fruit-based flavonoids is associated with cognitive benefits; however, the acute effects of flavonoid-rich (FR) drinks on cognitive function in the immediate postprandial period require examination. The objective was to investigate whether consumption of FR orange juice is associated with acute cognitive benefits over 6 h in healthy middle-aged adults.

Methods: Males aged 30-65 consumed a 240-ml FR orange juice (272 mg) and a calorie-matched placebo in a randomized, double-blind, counterbalanced order on 2 days separated by a 2-week washout. Cognitive function and subjective mood were assessed at baseline (prior to drink consumption) and 2 and 6 h post consumption. The cognitive battery included eight individual cognitive tests. A standardized breakfast was consumed prior to the baseline measures, and a standardized lunch was consumed 3 h post-drink consumption.

Results: Change from baseline analysis revealed that performance on tests of executive function and psychomotor speed was significantly better following the FR drink compared to the placebo. The effects of objective cognitive function were supported by significant benefits for subjective alertness following the FR drink relative to the placebo.

Conclusions: These data demonstrate that consumption of FR orange juice can acutely enhance objective and subjective cognition over the course of 6 h in healthy middle-aged adults.

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References

Dangour A, Allen E, Elbourne D, Fasey N, Fletcher A, Hardy P . Effect of 2-y n-3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trial. Am J Clin Nutr. 2010; 91(6):1725-32. DOI: 10.3945/ajcn.2009.29121. View

Palafox-Carlos H, Ayala-Zavala J, Gonzalez-Aguilar G . The role of dietary fiber in the bioaccessibility and bioavailability of fruit and vegetable antioxidants. J Food Sci. 2011; 76(1):R6-R15. PMC: 3052441. DOI: 10.1111/j.1750-3841.2010.01957.x. View

Krikorian R, Boespflug E, Fleck D, Stein A, Wightman J, Shidler M . Concord grape juice supplementation and neurocognitive function in human aging. J Agric Food Chem. 2012; 60(23):5736-42. DOI: 10.1021/jf300277g. View

Lamport D, Saunders C, Butler L, Spencer J . Fruits, vegetables, 100% juices, and cognitive function. Nutr Rev. 2014; 72(12):774-89. DOI: 10.1111/nure.12149. View

Rendeiro C, Vauzour D, Rattray M, Waffo-Teguo P, Merillon J, Butler L . Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor. PLoS One. 2013; 8(5):e63535. PMC: 3665790. DOI: 10.1371/journal.pone.0063535. View

Scholey A, French S, Morris P, Kennedy D, Milne A, Haskell C . Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort. J Psychopharmacol. 2009; 24(10):1505-14. DOI: 10.1177/0269881109106923. View

Field D, Williams C, Butler L . Consumption of cocoa flavanols results in an acute improvement in visual and cognitive functions. Physiol Behav. 2011; 103(3-4):255-60. DOI: 10.1016/j.physbeh.2011.02.013. View

Yamada T, Hayasaka S, Shibata Y, Ojima T, Saegusa T, Gotoh T . Frequency of citrus fruit intake is associated with the incidence of cardiovascular disease: the Jichi Medical School cohort study. J Epidemiol. 2011; 21(3):169-75. PMC: 3899405. DOI: 10.2188/jea.je20100084. View

Youdim K, Dobbie M, Gunter Kuhnle , Proteggente A, Abbott N, Rice-Evans C . Interaction between flavonoids and the blood-brain barrier: in vitro studies. J Neurochem. 2003; 85(1):180-92. DOI: 10.1046/j.1471-4159.2003.01652.x. View

10.

Krikorian R, Nash T, Shidler M, Shukitt-Hale B, Joseph J . Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr. 2009; 103(5):730-4. DOI: 10.1017/S0007114509992364. View

11.

Nielsen I, Chee W, Poulsen L, Offord-Cavin E, Rasmussen S, Frederiksen H . Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: a randomized, double-blind, crossover trial. J Nutr. 2006; 136(2):404-8. DOI: 10.1093/jn/136.2.404. View

12.

Schroeter H, Heiss C, Balzer J, Kleinbongard P, Keen C, Hollenberg N . (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci U S A. 2006; 103(4):1024-9. PMC: 1327732. DOI: 10.1073/pnas.0510168103. View

13.

Spencer J, Vafeiadou K, Williams R, Vauzour D . Neuroinflammation: modulation by flavonoids and mechanisms of action. Mol Aspects Med. 2011; 33(1):83-97. DOI: 10.1016/j.mam.2011.10.016. View

14.

Lamport D, Hoyle E, Lawton C, Mansfield M, Dye L . Evidence for a second meal cognitive effect: glycaemic responses to high and low glycaemic index evening meals are associated with cognition the following morning. Nutr Neurosci. 2011; 14(2):66-71. DOI: 10.1179/1476830511Y.0000000002. View

15.

Kean R, Lamport D, Dodd G, Freeman J, Williams C, Ellis J . Chronic consumption of flavanone-rich orange juice is associated with cognitive benefits: an 8-wk, randomized, double-blind, placebo-controlled trial in healthy older adults. Am J Clin Nutr. 2015; 101(3):506-14. DOI: 10.3945/ajcn.114.088518. View

16.

Brickman A, Khan U, Provenzano F, Yeung L, Suzuki W, Schroeter H . Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults. Nat Neurosci. 2014; 17(12):1798-803. PMC: 4940121. DOI: 10.1038/nn.3850. View

17.

Manach C, Morand C, Gil-Izquierdo A, Bouteloup-Demange C, Remesy C . Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice. Eur J Clin Nutr. 2003; 57(2):235-42. DOI: 10.1038/sj.ejcn.1601547. View

18.

de Jager C, Dye L, de Bruin E, Butler L, Fletcher J, Lamport D . Criteria for validation and selection of cognitive tests for investigating the effects of foods and nutrients. Nutr Rev. 2014; 72(3):162-79. DOI: 10.1111/nure.12094. View

19.

Dauchet L, Ferrieres J, Arveiler D, Yarnell J, Gey F, Ducimetiere P . Frequency of fruit and vegetable consumption and coronary heart disease in France and Northern Ireland: the PRIME study. Br J Nutr. 2004; 92(6):963-72. DOI: 10.1079/bjn20041286. View

20.

Fisher N, Hughes M, Gerhard-Herman M, Hollenberg N . Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans. J Hypertens. 2003; 21(12):2281-6. DOI: 10.1097/00004872-200312000-00016. View