Association of Mucosal Organisms with Patterns of Inflammation in Chronic Rhinosinusitis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Aug 15

PMID 26275068

Citations 16

Authors

Thanit Chalermwatanachai

Nan Zhang

Gabriele Holtappels

Claus Bachert

Affiliations

Soon will be listed here.

Abstract

Background: Chronic rhinosinusitis is a multifactorial process disease in which bacterial infection or colonization may play an important role in the initiation or persistence of inflammatory response. The association between mucosal bacteria presence and inflammatory patterns has only been partially explored.

Objective: To demonstrate specific mucosal microorganisms possible association with inflammatory patterns.

Methods: We collected nasal polyps or sinus tissues from a clinical selection of six patient groups with defined sinus disease using tissue biomarkers. In the tissues, we detected bacteria using peptide nucleic acid fluorescence in situ hybridization (PNA-FISH).

Results: After reviewing a total of 115 samples (15-20 samples per group), the mucosal presence of Staphylococcus aureus was correlated with IL-5 and SE-IgE positive chronic rhinosinusitis with nasal polyps and nasal polyps from cystic fibrosis patients. Chronic rhinosinusitis without nasal polyps with TNFα >20 pg/ml was associated with the mucosal presence of Pseudomonas aeruginosa.

Conclusion: This study identifies the relationship between intramucosal microbes and inflammatory patterns, suggesting that bacteria may affect the type of inflammation in chronic rhinosinusitis. Additional investigation is needed to further identify the nature of the relationship.

Citing Articles

Epithelial innate immune response to Pseudomonas aeruginosa-derived flagellin in chronic rhinosinusitis.

Li P, Sheng Q, Huang L, Turner J Int Forum Allergy Rhinol. 2023; 13(10):1937-1948.

PMID: 37057820 PMC: 10524325. DOI: 10.1002/alr.23164.

Chronic Rhinosinusitis, Biofilm and Secreted Products, Inflammatory Responses, and Disease Severity.

Shaghayegh G, Cooksley C, Ramezanpour M, Wormald P, Psaltis A, Vreugde S Biomedicines. 2022; 10(6).

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Unraveling the role of the microbiome in chronic rhinosinusitis.

Psaltis A, Wagner Mackenzie B, Cope E, Ramakrishnan V J Allergy Clin Immunol. 2022; 149(5):1513-1521.

PMID: 35300985 PMC: 9354834. DOI: 10.1016/j.jaci.2022.02.022.

Sinus Microbiota in Patients With Eosinophilic and Non-Eosinophilic Chronic Rhinosinusitis With Nasal Polyps.

Feng T, Miao P, Liu B, Liu Y, Bao X, Xu J Front Cell Infect Microbiol. 2021; 11:672355.

PMID: 34368010 PMC: 8346020. DOI: 10.3389/fcimb.2021.672355.

[The impact of endoscopic sinus surgery on sinonasal microbiome of chronic rhinosinusitis with nasal polyps].

Wu Y, Sun Y, Huang Z, Huang Q, Cui S, Li Y Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020; 34(12):1097-1102.

PMID: 33254343 PMC: 10127783. DOI: 10.13201/j.issn.2096-7993.2020.12.010.

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