Unraveling the Role of the Microbiome in Chronic Rhinosinusitis

Overview

Journal J Allergy Clin Immunol

Specialty Allergy & Immunology

Date 2022 Mar 18

PMID 35300985

Authors

Alkis J Psaltis

Brett Wagner Mackenzie

Emily K Cope

Vijay R Ramakrishnan

Affiliations

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Abstract

Chronic rhinosinusitis (CRS) is a complex, heterogenous condition that is likely associated with infectious and inflammatory causative factors. Renewed interest in the role that microbes play in this condition has stemmed from advancements in microbe identification and parallel research implicating the microbiome as having a role in other chronic inflammatory conditions. This clinical commentary provides a review of the current literature relevant to chronic rhinosinusitis. Particular focus is placed on factors specific to investigation of the sinonasal microbiome, evidence for the role of dysbiosis in the disease state, and influences that may affect the microbiome. Possible mechanisms of disease and therapeutic implications through microbial manipulation are also reviewed, as are deficiencies and limitations of the current body of research.

Citing Articles

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