Application of Good's Buffers to PH Imaging Using Hyperpolarized (13)C MRI

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2015 Aug 11

PMID 26257040

Citations 24

Authors

Robert R Flavell

Cornelius von Morze

Joseph E Blecha

David E Korenchan

Mark van Criekinge

Renuka Sriram

Jeremy W Gordon

Hsin-Yu Chen

Sukumar Subramaniam

Robert A Bok

Zhen J Wang

Daniel B Vigneron

Peder E Larson

John Kurhanewicz

David M Wilson

Affiliations

Soon will be listed here.

Abstract

N-(2-Acetamido)-2-aminoethanesulfonic acid (ACES), one of Good's buffers, was applied to pH imaging using hyperpolarized (13)C magnetic resonance spectroscopy. Rapid NMR- and MRI-based pH measurements were obtained by exploiting the sensitive pH-dependence of its (13)C chemical shift within the physiologic range.

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