Chemical Reaction-induced Multi-molecular Polarization (CRIMP)

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2014 Sep 17

PMID 25224323

Citations 10

Authors

Y Lee

N M Zacharias

D Piwnica-Worms

P K Bhattacharya

Affiliations

Soon will be listed here.

Abstract

Here we present a novel hyperpolarization method, Chemical Reaction-Induced Multi-molecular Polarization (CRIMP), which could be applied to the study of several in vivo processes simultaneously including glycolysis, TCA cycle, fatty acid synthesis and pH mapping. Through the use of non-enzymatic decarboxylation, we generate four hyperpolarized imaging agents from hyperpolarized 1,2-(13)C pyruvic acid.

Citing Articles

Hyperpolarized Magnetic Resonance and Artificial Intelligence: Frontiers of Imaging in Pancreatic Cancer.

Enriquez J, Chu Y, Pudakalakatti S, Hsieh K, Salmon D, Dutta P JMIR Med Inform. 2021; 9(6):e26601.

PMID: 34137725 PMC: 8277399. DOI: 10.2196/26601.

Indirect detection of intermediate in decarboxylation reaction of phenylglyoxylic acid by hyperpolarized C NMR.

Kim J, Kim Y, Luu Q, Kim J, Qi C, Hilty C Chem Commun (Camb). 2020; 56(95):15000-15003.

PMID: 33185204 PMC: 7886017. DOI: 10.1039/d0cc06331b.

Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-Time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia.

Zacharias N, Baran N, Shanmugavelandy S, Lee J, Lujan J, Dutta P Mol Cancer Ther. 2019; 18(11):1937-1946.

PMID: 31387889 PMC: 7080291. DOI: 10.1158/1535-7163.MCT-18-0985.

Assessing Therapeutic Efficacy in Real-time by Hyperpolarized Magnetic Resonance Metabolic Imaging.

Dutta P, Salzillo T, Pudakalakatti S, Gammon S, Kaipparettu B, McAllister F Cells. 2019; 8(4).

PMID: 30978984 PMC: 6523855. DOI: 10.3390/cells8040340.

Real-Time Interrogation of Aspirin Reactivity, Biochemistry, and Biodistribution by Hyperpolarized Magnetic Resonance Spectroscopy.

Zacharias N, Ornelas A, Lee J, Hu J, Davis J, Uddin N Angew Chem Int Ed Engl. 2019; 58(13):4179-4183.

PMID: 30680862 PMC: 6467058. DOI: 10.1002/anie.201812759.

References

Shostak A, Gotloib L, Kushnier R, Wajsbrot V . Protective effect of pyruvate upon cultured mesothelial cells exposed to 2 mM hydrogen peroxide. Nephron. 2000; 84(4):362-6. DOI: 10.1159/000045612. View

Oyama N, Okazawa H, Kusukawa N, Kaneda T, Miwa Y, Akino H . 11C-Acetate PET imaging for renal cell carcinoma. Eur J Nucl Med Mol Imaging. 2008; 36(3):422-7. DOI: 10.1007/s00259-008-0981-0. View

Bhattacharya P, Chekmenev E, Perman W, Harris K, Lin A, Norton V . Towards hyperpolarized (13)C-succinate imaging of brain cancer. J Magn Reson. 2007; 186(1):150-5. PMC: 2657725. DOI: 10.1016/j.jmr.2007.01.017. View

Nelson S, Kurhanewicz J, Vigneron D, Larson P, Harzstark A, Ferrone M . Metabolic imaging of patients with prostate cancer using hyperpolarized [1-¹³C]pyruvate. Sci Transl Med. 2013; 5(198):198ra108. PMC: 4201045. DOI: 10.1126/scitranslmed.3006070. View

Bhattacharya P, Ross B, Bunger R . Cardiovascular applications of hyperpolarized contrast media and metabolic tracers. Exp Biol Med (Maywood). 2009; 234(12):1395-416. DOI: 10.3181/0904-MR-135. View

Yoshii Y, Waki A, Furukawa T, Kiyono Y, Mori T, Yoshii H . Tumor uptake of radiolabeled acetate reflects the expression of cytosolic acetyl-CoA synthetase: implications for the mechanism of acetate PET. Nucl Med Biol. 2009; 36(7):771-7. DOI: 10.1016/j.nucmedbio.2009.05.006. View

Brindle K . Watching tumours gasp and die with MRI: the promise of hyperpolarised 13C MR spectroscopic imaging. Br J Radiol. 2012; 85(1014):697-708. PMC: 3474112. DOI: 10.1259/bjr/81120511. View

Golman K, Ardenkjaer-Larsen J, Petersson J, Mansson S, Leunbach I . Molecular imaging with endogenous substances. Proc Natl Acad Sci U S A. 2003; 100(18):10435-9. PMC: 193579. DOI: 10.1073/pnas.1733836100. View

Gallagher F, Kettunen M, Day S, Hu D, Ardenkjaer-Larsen J, In t Zandt R . Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate. Nature. 2008; 453(7197):940-3. DOI: 10.1038/nature07017. View

10.

Stavraka C, Pinato D, Turnbull S, Flynn M, Forster M, OCathail S . Developing an objective marker to optimize patient selection and predict survival benefit in early-phase cancer trials. Cancer. 2014; 120(2):262-70. DOI: 10.1002/cncr.28381. View

11.

Ardenkjaer-Larsen J, Johannesson H, Petersson J, Wolber J . Applications of hyperpolarized agents in solutions. Methods Mol Biol. 2011; 771:655-89. DOI: 10.1007/978-1-61779-219-9_33. View

12.

Ardenkjaer-Larsen J, Fridlund B, Gram A, Hansson G, Hansson L, Lerche M . Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR. Proc Natl Acad Sci U S A. 2003; 100(18):10158-63. PMC: 193532. DOI: 10.1073/pnas.1733835100. View

13.

Wilson D, Keshari K, Larson P, Chen A, Hu S, van Criekinge M . Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo. J Magn Reson. 2010; 205(1):141-7. PMC: 2885774. DOI: 10.1016/j.jmr.2010.04.012. View

14.

Hurd R, Yen Y, Chen A, Ardenkjaer-Larsen J . Hyperpolarized 13C metabolic imaging using dissolution dynamic nuclear polarization. J Magn Reson Imaging. 2012; 36(6):1314-28. DOI: 10.1002/jmri.23753. View

15.

Keshari K, Sriram R, van Criekinge M, Wilson D, Wang Z, Vigneron D . Metabolic reprogramming and validation of hyperpolarized 13C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor. Prostate. 2013; 73(11):1171-81. PMC: 3976546. DOI: 10.1002/pros.22665. View

16.

Desagher S, Glowinski J, Premont J . Pyruvate protects neurons against hydrogen peroxide-induced toxicity. J Neurosci. 1997; 17(23):9060-7. PMC: 6573585. View

17.

Ho C, Cheung M, Chen S, Cheung T, Leung Y, Cheng K . [18F]fluoroacetate positron emission tomography for hepatocellular carcinoma and metastases: an alternative tracer for [11C]acetate?. Mol Imaging. 2012; 11(3):229-39. View