Comparison of Dynamic Contrast-enhanced Magnetic Resonance Imaging with T2-weighted Imaging for Preoperative Staging of Early Endometrial Carcinoma

Overview

Journal Onco Targets Ther

Publisher Dove Medical Press

Specialty Oncology

Date 2015 Aug 1

PMID 26229482

Citations 3

Authors

Linfeng Zheng

Sujuan Zheng

Xiaochun Yuan

Xifu Wang

Zhuoli Zhang

Guixiang Zhang

Affiliations

Soon will be listed here.

Abstract

Purpose: This study aimed to compare dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with T2-weighted imaging (T2WI) for the preoperative staging of early endometrial carcinoma.

Methods: This retrospective study included 22 subjects with early endometrial carcinoma who underwent 3.0 T MRI examination prior to hysterectomy. DCE-MRI and T2WI were evaluated for the preoperative staging of endometrial carcinoma. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of DCE-MRI and T2WI were assessed and compared using the revised International Federation of Gynecology and Obstetrics surgical staging guidelines (2009) as the reference standard.

Results: Out of the 22 cases of endometrial carcinoma, the use of the reference standard method led to the staging of 14 as IA and eight as IB. The sensitivity, specificity, PPV, NPV, and accuracy of DCE-MRI for preoperative staging were 100% (95% confidence interval: 0.73-1.0), 62.5% (95% CI: 0.26-0.90), 82.4% (95% CI: 0.56-0.95), 100% (95% CI: 0.46-1.0), and 86.4%, respectively, and these values were 85.7% (95% CI: 0.56-0.97), 75% (95% CI: 0.36-0.96), 85.7% (95% CI: 0.56-0.97), 75% (95% CI: 0.36-0.96), and 81.8%, respectively, for T2WI. Thus, the sensitivity and accuracy of DCE-MRI were greater than those of T2WI for preoperative endometrial carcinoma staging.

Conclusion: DCE-MRI was more sensitive but less specific than T2WI for the preoperative staging of early endometrial carcinoma. DCE-MRI may serve as a useful and reliable tool for the preoperative assessment of endometrial carcinoma.

Citing Articles

A Comparison of Dynamic Contrast-Enhanced Magnetic Resonance Imaging and T2-Weighted Imaging in Determining the Depth of Myometrial Invasion in Endometrial Carcinoma-A Retrospective Study.

Nurdillah I, Rizuana I, Suraya A, Syazarina S J Pers Med. 2022; 12(8).

PMID: 36013217 PMC: 9410496. DOI: 10.3390/jpm12081268.

Endometrial carcinoma: use of tracer kinetic modeling of dynamic contrast-enhanced MRI for preoperative risk assessment.

Ye Z, Ning G, Li X, Koh T, Chen H, Bai W Cancer Imaging. 2022; 22(1):14.

PMID: 35264244 PMC: 8908697. DOI: 10.1186/s40644-022-00452-8.

Injection rate of contrast medium affects diagnostic ability of dynamic contrast-enhanced magnetic resonance imaging for endometrial carcinoma: a prospective cohort study.

Xu D, Jin A, Ge Y, Zhang Y Gland Surg. 2021; 10(8):2462-2470.

PMID: 34527558 PMC: 8411073. DOI: 10.21037/gs-21-374.

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