» Articles » PMID: 26221514

Photoreceptors in Diabetic Retinopathy

Overview
Specialty Endocrinology
Date 2015 Jul 30
PMID 26221514
Citations 74
Authors
Affiliations
Soon will be listed here.
Abstract

Although photoreceptors account for most of the mass and metabolic activity of the retina, their role in the pathogenesis of diabetic retinopathy has been largely overlooked. Recent studies suggest that photoreceptors might play a critical role in the diabetes-induced degeneration of retinal capillaries, and thus can no longer be ignored. The present review summarizes diabetes-induced alterations in photoreceptor structure and function, and provides a rationale for further study of a role of photoreceptors in the pathogenesis of the retinopathy.

Citing Articles

Relationship of fibroblast growth factor 21, Klotho, and diabetic retinopathy: a meta-analysis.

Jiang Y, Zhang W, Xu Y, Zeng X, Sun X Front Endocrinol (Lausanne). 2024; 15:1390035.

PMID: 39257905 PMC: 11384578. DOI: 10.3389/fendo.2024.1390035.


High-Resolution Imaging of Cones and Retinal Arteries in Patients with Diabetes Mellitus Type 1 Using Adaptive Optics (rtx1).

Matuszewski W, Szklarz M, Wolos-Klosowicz K, Harazny J, Bandurska-Stankiewicz E Biomedicines. 2024; 12(4).

PMID: 38672217 PMC: 11048079. DOI: 10.3390/biomedicines12040863.


Metformin and Glucose Concentration as Limiting Factors in Retinal Pigment Epithelial Cell Viability and Proliferation.

Villa-Fernandez E, Garcia A, Fernandez-Fernandez A, Garcia-Villarino M, Ares-Blanco J, Pujante P Int J Mol Sci. 2024; 25(5).

PMID: 38473884 PMC: 10932269. DOI: 10.3390/ijms25052637.


The glucocorticoid receptor as a master regulator of the Müller cell response to diabetic conditions in mice.

Pfaller A, Kaplan L, Carido M, Grassmann F, Diaz-Lezama N, Ghaseminejad F J Neuroinflammation. 2024; 21(1):33.

PMID: 38273366 PMC: 10809506. DOI: 10.1186/s12974-024-03021-x.


Outer Retinal and Choroidal Changes in Adolescents with Long-Lasting Type 1 Diabetes.

Pilotto E, Cosmo E, Torresin T, Coppola M, Gutierrez De Rubalcava Doblas J, Midena G J Clin Med. 2024; 13(1).

PMID: 38202235 PMC: 10779656. DOI: 10.3390/jcm13010229.


References
1.
Demontis G, Longoni B, Marchiafava P . Molecular steps involved in light-induced oxidative damage to retinal rods. Invest Ophthalmol Vis Sci. 2002; 43(7):2421-7. View

2.
Lin Y, Koretsky A . Manganese ion enhances T1-weighted MRI during brain activation: an approach to direct imaging of brain function. Magn Reson Med. 1997; 38(3):378-88. DOI: 10.1002/mrm.1910380305. View

3.
Forooghian F, Stetson P, Meyer S, Chew E, Wong W, Cukras C . Relationship between photoreceptor outer segment length and visual acuity in diabetic macular edema. Retina. 2009; 30(1):63-70. PMC: 3021331. DOI: 10.1097/IAE.0b013e3181bd2c5a. View

4.
Arden G, Sivaprasad S . The pathogenesis of early retinal changes of diabetic retinopathy. Doc Ophthalmol. 2012; 124(1):15-26. DOI: 10.1007/s10633-011-9305-y. View

5.
Barber A, Lieth E, Khin S, Antonetti D, Buchanan A, Gardner T . Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin. J Clin Invest. 1998; 102(4):783-91. PMC: 508941. DOI: 10.1172/JCI2425. View