Bruce A Berkowitz
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Explore the profile of Bruce A Berkowitz including associated specialties, affiliations and a list of published articles.
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97
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1657
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Recent Articles
1.
De Bruyn H, Johnson M, Moretti M, Ahmed S, Mujat M, Akula J, et al.
Diagnostics (Basel)
. 2024 Jul;
14(14).
PMID: 39061682
Stargardt disease (STGD1), associated with biallelic variants in the gene, is the most common heritable macular dystrophy and is currently untreatable. To identify potential treatment targets, we characterized surviving STGD1...
2.
Neto M, De Rossi G, Berkowitz B, Seabra M, Luthert P, Futter C, et al.
Cells
. 2024 Jul;
13(13.
PMID: 38994953
The retinal pigment epithelium (RPE) is an essential component of the retina that plays multiple roles required to support visual function. These include light onset- and circadian rhythm-dependent tasks, such...
3.
Berkowitz B, Paruchuri A, Stanek J, Abdul-Nabi M, Podolsky R, Bustos A, et al.
Acta Neuropathol Commun
. 2024 Jun;
12(1):85.
PMID: 38822433
Here, we test whether early visual and OCT rod energy-linked biomarkers indicating pathophysiology in nicotinamide nucleotide transhydrogenase (Nnt)-null 5xFAD mice also occur in Nnt-intact 5xFAD mice and whether these biomarkers...
4.
Berkowitz B, Paruchuri A, Stanek J, Podolsky R, Childers K, Roberts R
Invest Ophthalmol Vis Sci
. 2024 Mar;
65(3):21.
PMID: 38488413
Purpose: The purpose of this study was to test the hypothesis that optical coherence tomography (OCT) bioenergy-linked and anatomical biomarkers are responsive to an acetazolamide (ACZ) provocation. Methods: C57BL/6J mice...
5.
Goodman C, Podolsky R, Childers K, Roberts R, Katz R, Waseem R, et al.
Front Neurosci
. 2023 Dec;
17:1280453.
PMID: 38046657
Purpose: To test the hypothesis that rod photoreceptor mitochondria function progressively declines over time. Methods: 2, 12, and 24 month-old dark- and light-adapted C57BL/6J (B6J) mice were examined by OCT....
6.
Farias-Jofre M, Romero R, Galaz J, Xu Y, Miller D, Garcia-Flores V, et al.
EBioMedicine
. 2023 Nov;
98:104865.
PMID: 37944273
Background: Preterm birth preceded by spontaneous preterm labour often occurs in the clinical setting of sterile intra-amniotic inflammation (SIAI), a condition that currently lacks treatment. Methods: Proteomic and scRNA-seq human...
7.
Berkowitz B, Podolsky R, Childers K, Roberts R, Waseem R
Invest Ophthalmol Vis Sci
. 2023 Mar;
64(3):12.
PMID: 36867132
Purpose: In Alzheimer's disease, central brain neurons show evidence for early hyperactivity. It is unclear if this occurs in the retina, another disease target. Here, we tested for imaging biomarker...
8.
Berkowitz B, Podolsky R, Childers K, Roberts R, Katz R, Waseem R, et al.
Invest Ophthalmol Vis Sci
. 2022 Dec;
63(13):22.
PMID: 36576748
Purpose: To test the hypothesis that rod energy biomarkers in light and dark are similar in mice without functional rod transducin (Gnat1rd17). Methods: Gnat1rd17 and wildtype (WT) mice were studied...
9.
Gao S, Zeng Y, Li Y, Cohen E, Berkowitz B, Qian H
PNAS Nexus
. 2022 Nov;
1(4):pgac208.
PMID: 36338188
Fast (seconds) and slow (minutes to hours) optical coherence tomography (OCT) responses to light stimulation have been developed to probe outer retinal function with higher spatial resolution than the classical...
10.
Berkowitz B, Podolsky R, Childers K, Burgoyne T, De Rossi G, Qian H, et al.
Invest Ophthalmol Vis Sci
. 2022 Jul;
63(8):8.
PMID: 35816042
Purpose: To test the hypothesis that changing energy needs alter mitochondria distribution within the rod inner segment ellipsoid. Methods: In mice with relatively smaller (C57BL/6J [B6J]) or greater (129S6/ev [S6])...