Generation and Characterization of Novel Magnetic Field-Responsive Biomaterials

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Jul 25

PMID 26207995

Citations 14

Authors

Modesto T Lopez-Lopez

Giuseppe Scionti

Ana C Oliveira

Juan D G Duran

Antonio Campos

Miguel Alaminos

Ismael A Rodriguez

Affiliations

Soon will be listed here.

Abstract

We report the preparation of novel magnetic field-responsive tissue substitutes based on biocompatible multi-domain magnetic particles dispersed in a fibrin-agarose biopolymer scaffold. We characterized our biomaterials with several experimental techniques. First we analyzed their microstructure and found that it was strongly affected by the presence of magnetic particles, especially when a magnetic field was applied at the start of polymer gelation. In these samples we observed parallel stripes consisting of closely packed fibers, separated by more isotropic net-like spaces. We then studied the viability of oral mucosa fibroblasts in the magnetic scaffolds and found no significant differences compared to positive control samples. Finally, we analyzed the magnetic and mechanical properties of the tissue substitutes. Differences in microstructural patterns of the tissue substitutes correlated with their macroscopic mechanical properties. We also found that the mechanical properties of our magnetic tissue substitutes could be reversibly tuned by noncontact magnetic forces. This unique advantage with respect to other biomaterials could be used to match the mechanical properties of the tissue substitutes to those of potential target tissues in tissue engineering applications.

Citing Articles

Analysis of the Effect of Human Type I Collagen-Derived Peptide on Bone Regenerative Capacity and Comparison with Various Collagen Materials In Vivo.

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Alginate Hydrogels Reinforced by Dehydration under Stress-Application to a Soft Magnetic Actuator.

Leon-Cecilla A, Vazquez-Perez F, Gila-Vilchez C, Alvarez de Cienfuegos L, Lopez-Lopez M Gels. 2023; 9(1).

PMID: 36661805 PMC: 9858607. DOI: 10.3390/gels9010039.

Usefulness of a Nanostructured Fibrin-Agarose Bone Substitute in a Model of Severely Critical Mandible Bone Defect.

Martin-Piedra M, Girones-Camarasa B, Espana-Lopez A, Fernandez-Valades Gamez R, Blanco-Elices C, Garzon I Polymers (Basel). 2021; 13(22).

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Echogenic Advantages of Ferrogels Filled with Magnetic Sub-Microparticles.

Dinislamova O, Bugayova A, Shklyar T, Safronov A, Blyakhman F Bioengineering (Basel). 2021; 8(10).

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Rheology of magnetic colloids containing clusters of particle platelets and polymer nanofibres.

Abrougui M, Srasra E, Lopez-Lopez M, Duran J Philos Trans A Math Phys Eng Sci. 2020; 378(2171):20190255.

PMID: 32279638 PMC: 7202764. DOI: 10.1098/rsta.2019.0255.

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