Large Nosocomial Outbreak of Colistin-Resistant, Carbapenemase-Producing Klebsiella Pneumoniae Traced to Clonal Expansion of an MgrB Deletion Mutant

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2015 Jul 24

PMID 26202124

Citations 60

Authors

Tommaso Giani

Fabio Arena

Guendalina Vaggelli

Viola Conte

Adriana Chiarelli

Lucia Henrici De Angelis

Rossella Fornaini

Maddalena Grazzini

Fabrizio Niccolini

Patrizia Pecile

Gian Maria Rossolini

Affiliations

Soon will be listed here.

Abstract

We describe a large hospital outbreak (93 bloodstream infections) of colistin-resistant Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae isolates which was mirrored by increased colistin consumption. The outbreak was mostly traced to the clonal expansion of an mgrB deletion mutant of an ST512 strain that produced KPC-3.

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