Colistin Resistance Mechanisms in Klebsiella Pneumoniae Strains from Taiwan

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2015 Feb 19

PMID 25691646

Citations 82

Authors

Yi-Hsiang Cheng

Tzu-Lung Lin

Yi-Jiun Pan

Yu-Ping Wang

Yi-Tsung Lin

Jin-Town Wang

Affiliations

Soon will be listed here.

Abstract

Colistin is one of the antibiotics of last resort for the treatment of carbapenem-resistant Klebsiella pneumoniae infection. This study showed that capsular type K64 (50%) and ST11 (53.9%) are the prevalent capsular and sequence types in the colistin-resistant strains in Taiwan. The interruption of transcripts (38.5%) and amino acid mutation (15.4%) in mgrB are the major mechanisms contributing to colistin resistance. In addition, novel single amino acid changes in MgrB (Stop48Tyr) and PhoQ (Leu26Pro) were observed to contribute to colistin resistance.

Citing Articles

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Polymyxin resistance in Enterobacter cloacae complex in Brazil: phenotypic and molecular characterization.

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