A Newly Discovered Epidemic Area of Echinococcus Multilocularis in West Gansu Province in China

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Jul 18

PMID 26186219

Citations 10

Authors

Jian Han

Genshu Bao

Duoqiang Zhang

Pengcheng Gao

Tinjun Wu

Philip Craig

Patrick Giraudoux

Xiao Chen

Qi Xin

Lili He

Gen Chen

Tao Jing

Affiliations

Soon will be listed here.

Abstract

Alveolar echinococcosis (AE) is a lethal parasitic disease. In Gansu Province of China, all AE cases reported in literature were from Zhang and Min Counties, the southern part of the province. Here, we report the discovery of nine AE cases and one cystic echinococcosis (CE) case from Nanfeng Town of Minle County, in the middle of Hexi Corridor in west Gansu Province. The diagnosis of these cases were confirmed by serology, histopathology, computed tomography, B-ultrasound, immunohistochemistry method, DNA polymerase chain reaction and sequencing analysis. Because eight of nine AE cases came from First Zhanglianzhuang (FZLZ) village, we conducted preliminary epidemiological analyses of 730 persons on domestic water, community and ecology such as 356 dogs' faeces of FZLZ, in comparison with those of other five villages surrounding FZLZ. Our studies indicate that Nanfeng Town of Minle County is a newly discovered focus of AE in China as a CE and AE co-epidemic area. Further research of Echinococcus multilocularis transmission pattern in the area should be carried for prevention of this parasitic disease.

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References

Tappe D, Kern P, Frosch M, Kern P . A hundred years of controversy about the taxonomic status of Echinococcus species. Acta Trop. 2010; 115(3):167-74. DOI: 10.1016/j.actatropica.2010.03.001. View

Kern P . Clinical features and treatment of alveolar echinococcosis. Curr Opin Infect Dis. 2010; 23(5):505-12. DOI: 10.1097/QCO.0b013e32833d7516. View

McManus D, Li Z, Yang S, Gray D, Yang Y . Case studies emphasising the difficulties in the diagnosis and management of alveolar echinococcosis in rural China. Parasit Vectors. 2011; 4:196. PMC: 3197561. DOI: 10.1186/1756-3305-4-196. View

Zhang W, Zhang Z, Wu W, Shi B, Li J, Zhou X . Epidemiology and control of echinococcosis in central Asia, with particular reference to the People's Republic of China. Acta Trop. 2014; 141(Pt B):235-43. DOI: 10.1016/j.actatropica.2014.03.014. View

Craig P, Giraudoux P, Shi D, Bartholomot B, Barnish G, Delattre P . An epidemiological and ecological study of human alveolar echinococcosis transmission in south Gansu, China. Acta Trop. 2000; 77(2):167-77. DOI: 10.1016/s0001-706x(00)00134-0. View

Eckert J, Conraths F, Tackmann K . Echinococcosis: an emerging or re-emerging zoonosis?. Int J Parasitol. 2000; 30(12-13):1283-94. DOI: 10.1016/s0020-7519(00)00130-2. View

Zhou H, Chai S, Craig P, Delattre P, Quere J, Raoul F . Epidemiology of alveolar echinococcosis in Xinjiang Uygur autonomous region, China: a preliminary analysis. Ann Trop Med Parasitol. 2001; 94(7):715-29. DOI: 10.1080/00034983.2000.11813595. View

Jiang C . Today's regional distribution of echinococcosis in China. Chin Med J (Engl). 2003; 115(8):1244-7. View

Craig P . Epidemiology of human alveolar echinococcosis in China. Parasitol Int. 2005; 55 Suppl:S221-5. DOI: 10.1016/j.parint.2005.11.034. View

10.

Tiaoying L, Jiamin Q, Wen Y, Craig P, Xingwang C, Ning X . Echinococcosis in Tibetan populations, western Sichuan Province, China. Emerg Infect Dis. 2006; 11(12):1866-73. PMC: 3367622. DOI: 10.3201/eid1112.050079. View

11.

Liccioli S, Duignan P, Lejeune M, Deunk J, Majid S, Massolo A . A new intermediate host for Echinococcus multilocularis: the southern red-backed vole (Myodes gapperi) in urban landscape in Calgary, Canada. Parasitol Int. 2013; 62(4):355-7. DOI: 10.1016/j.parint.2013.03.007. View

12.

Beiromvand M, Akhlaghi L, Fattahi Massom S, Meamar A, Darvish J, Razmjou E . Molecular identification of Echinococcus multilocularis infection in small mammals from Northeast, Iran. PLoS Negl Trop Dis. 2013; 7(7):e2313. PMC: 3708880. DOI: 10.1371/journal.pntd.0002313. View

13.

Moss J, Chen X, Li T, Qiu J, Wang Q, Giraudoux P . Reinfection studies of canine echinococcosis and role of dogs in transmission of Echinococcus multilocularis in Tibetan communities, Sichuan, China. Parasitology. 2013; 140(13):1685-92. PMC: 3806043. DOI: 10.1017/S0031182013001200. View

14.

Tanner F, Hegglin D, Thoma R, Brosi G, Deplazes P . [Echinococcus multilocularis in Grisons: distribution in foxes and presence of potential intermediate hosts]. Schweiz Arch Tierheilkd. 2006; 148(9):501-10. DOI: 10.1024/0036-7281.148.9.501. View

15.

Yang Y, Craig P, Sun T, Vuitton D, Giraudoux P, Jones M . Echinococcosis in Ningxia Hui Autonomous Region, northwest China. Trans R Soc Trop Med Hyg. 2008; 102(4):319-28. DOI: 10.1016/j.trstmh.2008.01.007. View

16.

Li T, Ito A, Nakaya K, Qiu J, Nakao M, Zhen R . Species identification of human echinococcosis using histopathology and genotyping in northwestern China. Trans R Soc Trop Med Hyg. 2008; 102(6):585-90. PMC: 2517144. DOI: 10.1016/j.trstmh.2008.02.019. View

17.

Schneider R, Gollackner B, Edel B, Schmid K, Wrba F, Tucek G . Development of a new PCR protocol for the detection of species and genotypes (strains) of Echinococcus in formalin-fixed, paraffin-embedded tissues. Int J Parasitol. 2008; 38(8-9):1065-71. DOI: 10.1016/j.ijpara.2007.11.008. View

18.

Wang Z, Wang X, Liu X . Echinococcosis in China, a review of the epidemiology of Echinococcus spp. Ecohealth. 2008; 5(2):115-26. DOI: 10.1007/s10393-008-0174-0. View

19.

Moro P, Schantz P . Echinococcosis: a review. Int J Infect Dis. 2008; 13(2):125-33. DOI: 10.1016/j.ijid.2008.03.037. View

20.

Wang C, He H, Li M, Lei F, Root J, Wu Y . Parasite species associated with wild plateau pika (Ochotona curzoniae) in southeastern Qinghai Province, China. J Wildl Dis. 2009; 45(2):288-94. DOI: 10.7589/0090-3558-45.2.288. View