High-Resolution Metabolomics: Review of the Field and Implications for Nursing Science and the Study of Preterm Birth

Overview

Journal Biol Res Nurs

Specialties Biology
Nursing

Date 2015 Jul 18

PMID 26183181

Citations 16

Authors

Shuzhao Li

Anne L Dunlop

Dean P Jones

Elizabeth J Corwin

Affiliations

Soon will be listed here.

Abstract

Most complex health conditions do not have a single etiology but rather develop from exposure to multiple risk factors that interact to influence individual susceptibility. In this review, we discuss the emerging field of metabolomics as a means by which metabolic pathways underlying a disease etiology can be exposed and specific metabolites can be identified and linked, ultimately providing biomarkers for early detection of disease onset and new strategies for intervention. We present the theoretical foundation of metabolomics research, the current methods employed in its conduct, and the overlap of metabolomics research with other "omic" approaches. As an exemplar, we discuss the potential of metabolomics research in the context of deciphering the complex interactions of the maternal-fetal exposures that underlie the risk of preterm birth, a condition that accounts for substantial portions of infant morbidity and mortality and whose etiology and pathophysiology remain incompletely defined. We conclude by providing strategies for including metabolomics research in future nursing studies for the advancement of nursing science.

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