Biomarkers of Delayed Graft Function As a Form of Acute Kidney Injury in Kidney Transplantation

Overview

Journal Sci Rep

Specialty Science

Date 2015 Jul 16

PMID 26175216

Citations 28

Authors

Jolanta Malyszko

Ewelina Lukaszyk

Irena Glowinska

Magdalena Durlik

Affiliations

Soon will be listed here.

Abstract

Renal transplantation ensures distinct advantages for patients with end-stage kidney disease. However, in some cases early complications can lead to allograft dysfunction and consequently graft loss. One of the most common early complications after kidney transplantation is delayed graft function (DGF). Unfortunately there is no effective treatment for DGF, however early diagnosis of DGF and therapeutic intervention (eg modification of immunosuppression) may improve outcome. Therefore, markers of acute kidney injury are required. Creatinine is a poor biomarker for kidney injury due principally to its inability to help diagnose early acute renal failure and complete inability to help differentiate among its various causes. Different urinary and serum proteins have been intensively investigated as possible biomarkers in this setting. There are promising candidate biomarkers with the ability to detect DGF. We focused on emerging biomarkers of DGF with NGAL is being the most studied followed by KIM-1, L-FABP, IL-18, and others. However, large randomized studies are needed to establish the value of new, promising biomarkers, in DGF diagnosis, prognosis and its cost-effectiveness.

Citing Articles

The Evaluation of Serum KIM-1 in a Pediatric Cohort of Renal Transplantation-A Pilot Study.

Aldea P, Turbuleasa-Jurje R, Bulata B, Delean D, Elec F, Ciumarnean L Children (Basel). 2025; 12(1).

PMID: 39857894 PMC: 11764347. DOI: 10.3390/children12010063.

An integrated machine learning model enhances delayed graft function prediction in pediatric renal transplantation from deceased donors.

Liu X, Feng R, Feng W, Jiang W, Chen J, Zhong G BMC Med. 2024; 22(1):407.

PMID: 39304842 PMC: 11415997. DOI: 10.1186/s12916-024-03624-4.

Empowering an Acute Kidney Injury 3D Graphene-Based Sensor Using Extreme Learning Machine.

Sittihakote N, Danvirutai P, Anutrakulchai S, Tuantranont A, Srichan C ACS Omega. 2024; 9(19):21276-21286.

PMID: 38764614 PMC: 11097169. DOI: 10.1021/acsomega.4c01315.

Royal Jelly, A Super Food, Protects Against Celecoxib-Induced Renal Toxicity in Adult Male Albino Rats.

Khalifa H, Eleiwa N, Nazim H Can J Kidney Health Dis. 2024; 11:20543581241235526.

PMID: 38476622 PMC: 10929035. DOI: 10.1177/20543581241235526.

Fatty-Acid-Binding Proteins: From Lipid Transporters to Disease Biomarkers.

Gaffar S, Aathirah A Biomolecules. 2023; 13(12).

PMID: 38136624 PMC: 10741572. DOI: 10.3390/biom13121753.

References

Waikar S, Betensky R, Bonventre J . Creatinine as the gold standard for kidney injury biomarker studies?. Nephrol Dial Transplant. 2009; 24(11):3263-5. DOI: 10.1093/ndt/gfp428. View

de Geus H, Bakker J, Lesaffre E, le Noble J . Neutrophil gelatinase-associated lipocalin at ICU admission predicts for acute kidney injury in adult patients. Am J Respir Crit Care Med. 2010; 183(7):907-14. DOI: 10.1164/rccm.200908-1214OC. View

Kjeldsen L, Johnsen A, Sengelov H, Borregaard N . Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem. 1993; 268(14):10425-32. View

Tong Z, Wu X, Ovcharenko D, Zhu J, Chen C, Kehrer J . Neutrophil gelatinase-associated lipocalin as a survival factor. Biochem J. 2005; 391(Pt 2):441-8. PMC: 1276944. DOI: 10.1042/BJ20051020. View

Oyama Y, Takeda T, Hama H, Tanuma A, Iino N, Sato K . Evidence for megalin-mediated proximal tubular uptake of L-FABP, a carrier of potentially nephrotoxic molecules. Lab Invest. 2005; 85(4):522-31. DOI: 10.1038/labinvest.3700240. View

Mishra J, Dent C, Tarabishi R, Mitsnefes M, Ma Q, Kelly C . Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet. 2005; 365(9466):1231-8. DOI: 10.1016/S0140-6736(05)74811-X. View

Parikh C, Devarajan P, Zappitelli M, Sint K, Thiessen-Philbrook H, Li S . Postoperative biomarkers predict acute kidney injury and poor outcomes after pediatric cardiac surgery. J Am Soc Nephrol. 2011; 22(9):1737-47. PMC: 3171944. DOI: 10.1681/ASN.2010111163. View

Lechevallier E, Dussol B, Luccioni A, Thirion X, Jaber K, Brunet P . Posttransplantation acute tubular necrosis: risk factors and implications for graft survival. Am J Kidney Dis. 1998; 32(6):984-91. DOI: 10.1016/s0272-6386(98)70073-3. View

Koyner J, Bennett M, Worcester E, Ma Q, Raman J, Jeevanandam V . Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery. Kidney Int. 2008; 74(8):1059-69. PMC: 2745082. DOI: 10.1038/ki.2008.341. View

10.

Yamamoto T, Noiri E, Ono Y, Doi K, Negishi K, Kamijo A . Renal L-type fatty acid--binding protein in acute ischemic injury. J Am Soc Nephrol. 2007; 18(11):2894-902. DOI: 10.1681/ASN.2007010097. View

11.

Bachorzewska-Gajewska H, Malyszko J, Sitniewska E, Malyszko J, Dobrzycki S . Neutrophil-gelatinase-associated lipocalin and renal function after percutaneous coronary interventions. Am J Nephrol. 2006; 26(3):287-92. DOI: 10.1159/000093961. View

12.

Waikar S, Bonventre J . Creatinine kinetics and the definition of acute kidney injury. J Am Soc Nephrol. 2009; 20(3):672-9. PMC: 2653692. DOI: 10.1681/ASN.2008070669. View

13.

Wagener G, Gubitosa G, Wang S, Borregaard N, Kim M, Lee H . Urinary neutrophil gelatinase-associated lipocalin and acute kidney injury after cardiac surgery. Am J Kidney Dis. 2008; 52(3):425-33. DOI: 10.1053/j.ajkd.2008.05.018. View

14.

Malyszko J . Biomarkers of acute kidney injury in different clinical settings: a time to change the paradigm?. Kidney Blood Press Res. 2010; 33(5):368-82. DOI: 10.1159/000319505. View

15.

Han W, Wagener G, Zhu Y, Wang S, Lee H . Urinary biomarkers in the early detection of acute kidney injury after cardiac surgery. Clin J Am Soc Nephrol. 2009; 4(5):873-82. PMC: 2676184. DOI: 10.2215/CJN.04810908. View

16.

Bennett M, Dent C, Ma Q, Dastrala S, Grenier F, Workman R . Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study. Clin J Am Soc Nephrol. 2008; 3(3):665-73. PMC: 2386703. DOI: 10.2215/CJN.04010907. View

17.

Ichimura T, Bonventre J, Bailly V, Wei H, Hession C, Cate R . Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J Biol Chem. 1998; 273(7):4135-42. DOI: 10.1074/jbc.273.7.4135. View

18.

Sharma A, Tolani S, Rathi G, Sharma P, Gupta H, Gupta R . Evaluation of factors causing delayed graft function in live related donor renal transplantation. Saudi J Kidney Dis Transpl. 2010; 21(2):242-5. View

19.

Siew E, Ikizler T, Gebretsadik T, Shintani A, Wickersham N, Bossert F . Elevated urinary IL-18 levels at the time of ICU admission predict adverse clinical outcomes. Clin J Am Soc Nephrol. 2010; 5(8):1497-505. PMC: 2924408. DOI: 10.2215/CJN.09061209. View

20.

Parikh C, Jani A, Melnikov V, Faubel S, Edelstein C . Urinary interleukin-18 is a marker of human acute tubular necrosis. Am J Kidney Dis. 2004; 43(3):405-14. DOI: 10.1053/j.ajkd.2003.10.040. View