Fatty-Acid-Binding Proteins: From Lipid Transporters to Disease Biomarkers

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2023 Dec 23

PMID 38136624

Authors

Shabarni Gaffar

A Sayyidatina Aathirah

Affiliations

Soon will be listed here.

Abstract

Fatty-acid-binding proteins (FABPs) serve a crucial role in the metabolism and transport of fatty acids and other hydrophobic ligands as an intracellular protein family. They are also recognized as a critical mediator in the inflammatory and ischemic pathways. FABPs are found in a wide range of tissues and organs, allowing them to contribute to various disease/injury developments that have not been widely discussed. We have collected and analyzed research journals that have investigated the role of FABPs in various diseases. Through this review, we discuss the findings on the potential of FABPs as biomarkers for various diseases in different tissues and organs, looking at their expression levels and their roles in related diseases according to available literature data. FABPs have been reported to show significantly increased expression levels in various tissues and organs associated with metabolic and inflammatory diseases. Therefore, FABPs are a promising novel biomarker that needs further development to optimize disease diagnosis and prognosis methods along with previously discovered markers.

Citing Articles

Intestinal Microbiota Dysbiosis Role and Bacterial Translocation as a Factor for Septic Risk.

Charitos I, Scacco S, Cotoia A, Castellaneta F, Castellana G, Pasqualotto F Int J Mol Sci. 2025; 26(5).

PMID: 40076650 PMC: 11900423. DOI: 10.3390/ijms26052028.

The follow-up of patients with celiac disease.

Di Tola M, Bontkes H, Irure-Ventura J, Lopez-Hoyos M, Bizzaro N J Transl Autoimmun. 2025; 10:100278.

PMID: 39981115 PMC: 11840481. DOI: 10.1016/j.jtauto.2025.100278.

Integrated Transcriptome Profiling and Pan-Cancer Analyses Reveal Oncogenic Networks and Tumor-Immune Modulatory Roles for FABP7 in Brain Cancers.

Lee Y, Flores C, Lefton M, Bhoumik S, Owada Y, Gerstner J Int J Mol Sci. 2024; 25(22).

PMID: 39596296 PMC: 11594725. DOI: 10.3390/ijms252212231.

Identification of conserved and tissue-restricted transcriptional profiles for lipid associated macrophages (LAMs).

Xu Y, Hillman H, Chang M, Ivanov S, Williams J bioRxiv. 2024; .

PMID: 39386558 PMC: 11463620. DOI: 10.1101/2024.09.24.614807.

CPT2 Deficiency Modeled in Zebrafish: Abnormal Neural Development, Electrical Activity, Behavior, and Schizophrenia-Related Gene Expression.

Baker C, Marta A, Zimmerman N, Korade Z, Mathy N, Wilton D Biomolecules. 2024; 14(8).

PMID: 39199302 PMC: 11353230. DOI: 10.3390/biom14080914.

References

Hotamisligil G, Bernlohr D . Metabolic functions of FABPs--mechanisms and therapeutic implications. Nat Rev Endocrinol. 2015; 11(10):592-605. PMC: 4578711. DOI: 10.1038/nrendo.2015.122. View

Smathers R, Petersen D . The human fatty acid-binding protein family: evolutionary divergences and functions. Hum Genomics. 2011; 5(3):170-91. PMC: 3500171. DOI: 10.1186/1479-7364-5-3-170. View

Ju J, Wang N, Wang J, Wu F, Ge J, Chen F . 4-Amino-2-trifluoromethyl-phenyl retinate inhibits proliferation, invasion, and migration of breast cancer cells by independently regulating CRABP2 and FABP5. Drug Des Devel Ther. 2018; 12:997-1008. PMC: 5927060. DOI: 10.2147/DDDT.S151029. View

Karvellas C, Speiser J, Tremblay M, Lee W, Rose C . Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure. Hepatology. 2016; 65(3):938-949. PMC: 5319885. DOI: 10.1002/hep.28945. View

Graupera I, Coll M, Pose E, Elia C, Piano S, Sola E . Adipocyte Fatty-Acid Binding Protein is Overexpressed in Cirrhosis and Correlates with Clinical Outcomes. Sci Rep. 2017; 7(1):1829. PMC: 5431836. DOI: 10.1038/s41598-017-01709-0. View

Hao J, Yan F, Zhang Y, Triplett A, Zhang Y, Schultz D . Expression of Adipocyte/Macrophage Fatty Acid-Binding Protein in Tumor-Associated Macrophages Promotes Breast Cancer Progression. Cancer Res. 2018; 78(9):2343-2355. PMC: 5932212. DOI: 10.1158/0008-5472.CAN-17-2465. View

Zhao J, Yuan Q, Wang H, Liu W, Liao X, Su Y . Antibody Responses to SARS-CoV-2 in Patients With Novel Coronavirus Disease 2019. Clin Infect Dis. 2020; 71(16):2027-2034. PMC: 7184337. DOI: 10.1093/cid/ciaa344. View

Hou Q, Bing Z, Hu C, Li M, Yang K, Mo Z . RankProd Combined with Genetic Algorithm Optimized Artificial Neural Network Establishes a Diagnostic and Prognostic Prediction Model that Revealed C1QTNF3 as a Biomarker for Prostate Cancer. EBioMedicine. 2018; 32:234-244. PMC: 6021271. DOI: 10.1016/j.ebiom.2018.05.010. View

Furuhashi M, Hotamisligil G . Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov. 2008; 7(6):489-503. PMC: 2821027. DOI: 10.1038/nrd2589. View

10.

Powell C, Nasser M, Zhao H, Wochna J, Zhang X, Shapiro C . Fatty acid binding protein 5 promotes metastatic potential of triple negative breast cancer cells through enhancing epidermal growth factor receptor stability. Oncotarget. 2015; 6(8):6373-85. PMC: 4467443. DOI: 10.18632/oncotarget.3442. View

11.

Liu F, Liu W, Zhou S, Yang C, Tian M, Jia G . Identification of FABP5 as an immunometabolic marker in human hepatocellular carcinoma. J Immunother Cancer. 2020; 8(2). PMC: 7332195. DOI: 10.1136/jitc-2019-000501. View

12.

Varrone F, Gargano B, Carullo P, Silvestre D, de Palma A, Grasso L . The circulating level of FABP3 is an indirect biomarker of microRNA-1. J Am Coll Cardiol. 2012; 61(1):88-95. DOI: 10.1016/j.jacc.2012.08.1003. View

13.

Xu B, Chen L, Zhan Y, S Marquez K, Zhuo L, Qi S . The Biological Functions and Regulatory Mechanisms of Fatty Acid Binding Protein 5 in Various Diseases. Front Cell Dev Biol. 2022; 10:857919. PMC: 9013884. DOI: 10.3389/fcell.2022.857919. View

14.

Malhotra R, Siew E . Biomarkers for the Early Detection and Prognosis of Acute Kidney Injury. Clin J Am Soc Nephrol. 2016; 12(1):149-173. PMC: 5220647. DOI: 10.2215/CJN.01300216. View

15.

Vermeulen Windsant I, Hellenthal F, Derikx J, Prins M, Buurman W, Jacobs M . Circulating intestinal fatty acid-binding protein as an early marker of intestinal necrosis after aortic surgery: a prospective observational cohort study. Ann Surg. 2012; 255(4):796-803. DOI: 10.1097/SLA.0b013e31824b1e16. View

16.

Carbonetti G, Wilpshaar T, Kroonen J, Studholme K, Converso C, dOelsnitz S . FABP5 coordinates lipid signaling that promotes prostate cancer metastasis. Sci Rep. 2019; 9(1):18944. PMC: 6908725. DOI: 10.1038/s41598-019-55418-x. View

17.

Schurink M, Scholten I, Kooi E, Hulzebos C, Kox R, Groen H . Intestinal fatty acid-binding protein in neonates with imminent necrotizing enterocolitis. Neonatology. 2014; 106(1):49-54. DOI: 10.1159/000358582. View

18.

Gajda A, Storch J . Enterocyte fatty acid-binding proteins (FABPs): different functions of liver and intestinal FABPs in the intestine. Prostaglandins Leukot Essent Fatty Acids. 2014; 93:9-16. PMC: 4323920. DOI: 10.1016/j.plefa.2014.10.001. View

19.

Korff S, Katus H, Giannitsis E . Differential diagnosis of elevated troponins. Heart. 2006; 92(7):987-93. PMC: 1860726. DOI: 10.1136/hrt.2005.071282. View

20.

Iwayama Y, Hattori E, Maekawa M, Yamada K, Toyota T, Ohnishi T . Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2009; 153B(2):484-493. DOI: 10.1002/ajmg.b.31004. View