Severe Disturbance of Glucose Metabolism in Peripheral Blood Mononuclear Cells of Schizophrenia Patients: a Targeted Metabolomic Study

Overview

Journal J Transl Med

Publisher Biomed Central

Specialties Biomedical Engineering
General Medicine

Date 2015 Jul 15

PMID 26169624

Citations 25

Authors

Mei-Ling Liu

Xiao-Tong Zhang

Xiang-Yu Du

Zheng Fang

Zhao Liu

Yi Xu

Peng Zheng

Xue-Jiao Xu

Peng-Fei Cheng

Ting Huang

Shun-Jie Bai

Li-Bo Zhao

Zhi-Guo Qi

Wei-Hua Shao

Peng Xie

Affiliations

Soon will be listed here.

Abstract

Background: Schizophrenia is a widespread and debilitating mental disorder. However, the underlying molecular mechanism of schizophrenia remains largely unknown and no objective laboratory tests are available to diagnose this disorder. The aim of the present study was to characterize the alternations of glucose metabolites and identify potential diagnostic biomarkers for schizophrenia.

Methods: Gas chromatography/mass spectrometry based targeted metabolomic method was used to quantify the levels of 13 glucose metabolites in peripheral blood mononuclear cells (PBMCs) derived from healthy controls, schizophrenia and major depression subjects (n = 55 for each group).

Results: The majority (84.6%) of glucose metabolites were significantly disturbed in schizophrenia subjects, while only two (15.4%) glucose metabolites were differently expressed in depression subjects relative to healthy controls in both training set (n = 35/group) and test set (n = 20/group). Antipsychotics had only a subtle effect on glucose metabolism pathway. Moreover, ribose 5-phosphate in PBMCs showed a high diagnostic performance for first-episode drug-naïve schizophrenia subjects.

Conclusion: These findings suggested disturbance of glucose metabolism may be implicated in onset of schizophrenia and could aid in development of diagnostic tool for this disorder.

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