Superovulation Induced Changes of Lipid Metabolism in Ovaries and Embryos and Its Probable Mechanism

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Jul 14

PMID 26167919

Citations 15

Authors

Li-Ya Wang

Ning Wang

Fang LE

Lei Li

Hang-Ying Lou

Xiao-Zhen Liu

Ying-Ming Zheng

Ye-Qing Qian

Yun-Long Chen

Xin-Hang Jiang

He-Feng Huang

Fan Jin

Affiliations

Soon will be listed here.

Abstract

This research was intended to investigate the fetal origins of changed birth weight of the offspring born through assisted reproductive technology (ART). The association between hormone and lipid metabolism or body weight has been generally accepted, and as the basic and specific treatment in ART procedure, gonadotropin stimulation might have potential effects on intrauterine lipid metabolism. In our studies, the mice were superovulated with two doses of gonadotropin. The cholesterol metabolism in ovaries and the triglyceride metabolism in embryos were analyzed. The results showed gonadotropin probably accelerated luteinization and induced a longer time follicle development and ovulation, which resulted in histological and morphological alteration of ovary, and increased the cholesterol content and the expressions of steroidogenesis-related genes. In embryos, gonadotropin increased lipid accumulation and decreased fatty acid synthesis in a dose-dependent manner. Moreover, the changes of fatty acid composition were also shown in superovulation groups. Our studies firstly provided the evidence that the superovulation might affect the maternal and fetal lipid metabolism. These variations of lipid metabolism in our results may be associated with birth weight of ART infants.

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