Gestational Bisphenol A Exposure and Testis Development

Overview

Journal Endocr Disruptors (Austin)

Date 2015 Jul 14

PMID 26167515

Citations 11

Authors

Cecilia Williams

Maria Bondesson

Dimitry N Krementsov

Cory Teuscher

Affiliations

Soon will be listed here.

Abstract

Virtually all humans are exposed to bisphenol A (BPA). Since BPA can act as a ligand for estrogen receptors, potential hazardous effects of BPA should be evaluated in the context of endogenous estrogenic hormones. Because estrogen is metabolized in the placenta, developing fetuses are normally exposed to very low endogenous estrogen levels. BPA, on the other hand, passes through the placenta and might have distinct adverse consequences during the sensitive stages of fetal development. Testicular gametogenesis and steroidogenesis begin early during fetal development. These processes are sensitive to estrogens and play a role in determining the number of germ stem cells, sperm count, and male hormone levels in adulthood. Although studies have shown a correlation between BPA exposure and perturbed reproduction, a clear consensus has yet to be established as to whether current human gestational BPA exposure results in direct adverse effects on male genital development and reproduction. However, studies in animals and in vitro have provided direct evidence for the ability of BPA exposure to influence male reproductive development. This review discusses the current knowledge of potential effects of BPA exposure on male reproductive health and whether gestational exposure adversely affects testis development.

Citing Articles

Melatonin alleviates oxidative stress damage in mouse testes induced by bisphenol A.

Qi Q, Yang J, Li S, Liu J, Xu D, Wang G Front Cell Dev Biol. 2024; 12:1338828.

PMID: 38440074 PMC: 10910031. DOI: 10.3389/fcell.2024.1338828.

Bisphenol-A disturbs hormonal levels and testis mitochondrial activity, reducing male fertility.

Ryu D, Pang W, Adegoke E, Rahman M, Park Y, Pang M Hum Reprod Open. 2023; 2023(4):hoad044.

PMID: 38021376 PMC: 10681812. DOI: 10.1093/hropen/hoad044.

Resveratrol ameliorates bisphenol A-induced testicular toxicity in adult male rats: a stereological and functional study.

Bordbar H, Yahyavi S, Noorafshan A, Aliabadi E, Naseh M Basic Clin Androl. 2023; 33(1):1.

PMID: 36604652 PMC: 9817316. DOI: 10.1186/s12610-022-00174-8.

REPRODUCTIVE TOXICOLOGY: Environmental exposures, fetal testis development and function: phthalates and beyond.

Li H, Spade D Reproduction. 2021; 162(5):F147-F167.

PMID: 34314370 PMC: 8497445. DOI: 10.1530/REP-20-0592.

Bisphenol AF and Bisphenol F Induce Similar Feminizing Effects in Chicken Embryo Testis as Bisphenol A.

Mentor A, Wann M, Brunstrom B, Jonsson M, Mattsson A Toxicol Sci. 2020; 178(2):239-250.

PMID: 33010167 PMC: 7706397. DOI: 10.1093/toxsci/kfaa152.

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