In Vivo Effects of Bisphenol A in Laboratory Rodent Studies

Overview

Journal Reprod Toxicol

Specialties Reproductive Medicine
Toxicology

Date 2007 Aug 9

PMID 17683900

Citations 379

Authors

Catherine A Richter

Linda S Birnbaum

Francesca Farabollini

Retha R Newbold

Beverly S Rubin

Chris E Talsness

John G Vandenbergh

Debby R Walser-Kuntz

Frederick S Vom Saal

Affiliations

Soon will be listed here.

Abstract

Concern is mounting regarding the human health and environmental effects of bisphenol A (BPA), a high-production-volume chemical used in synthesis of plastics. We have reviewed the growing literature on effects of low doses of BPA, below 50 mg/(kg day), in laboratory exposures with mammalian model organisms. Many, but not all, effects of BPA are similar to effects seen in response to the model estrogens diethylstilbestrol and ethinylestradiol. For most effects, the potency of BPA is approximately 10-1000-fold less than that of diethylstilbestrol or ethinylestradiol. Based on our review of the literature, a consensus was reached regarding our level of confidence that particular outcomes occur in response to low dose BPA exposure. We are confident that adult exposure to BPA affects the male reproductive tract, and that long lasting, organizational effects in response to developmental exposure to BPA occur in the brain, the male reproductive system, and metabolic processes. We consider it likely, but requiring further confirmation, that adult exposure to BPA affects the brain, the female reproductive system, and the immune system, and that developmental effects occur in the female reproductive system.

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