Relationship Between Outer Retinal Layers Thickness and Visual Acuity in Diabetic Macular Edema

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2015 Jul 14

PMID 26167510

Citations 12

Authors

Raymond L M Wong

Jacky W Y Lee

Gordon S K Yau

Ian Y H Wong

Affiliations

Soon will be listed here.

Abstract

Purpose: To investigate the correlation of outer retinal layers (ORL) thickness and visual acuity (VA) in patients with diabetic macular edema (DME).

Methods: Consecutive DME patients seen at the Retina Clinic of The University of Hong Kong were recruited for OCT assessment. The ORL thickness was defined as the distance between external limiting membrane (ELM) and retinal pigment epithelium (RPE) at the foveal center. The correlation between total retinal thickness, ORL thickness, and vision was calculated.

Results: 78 patients with DME were recruited. The mean age was 58.1 years (±11.5 years) and their mean visual acuity measured with Snellen chart was 0.51 (±0.18). The correlation coefficient between total retinal thickness and visual acuity was 0.34 (P < 0.001) whereas the correlation coefficient was 0.65 between ORL thickness and visual acuity (P < 0.001).

Conclusion: ORL thickness correlates better with vision than the total retinal thickness. It is a novel OCT parameter in the assessment of DME. Moreover, it could be a potential long term visual prognostic factor for patients with DME.

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References

Lang G, Berta A, Eldem B, Simader C, Sharp D, Holz F . Two-year safety and efficacy of ranibizumab 0.5 mg in diabetic macular edema: interim analysis of the RESTORE extension study. Ophthalmology. 2013; 120(10):2004-12. DOI: 10.1016/j.ophtha.2013.02.019. View

Nguyen Q, Brown D, Marcus D, Boyer D, Patel S, Feiner L . Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE. Ophthalmology. 2012; 119(4):789-801. DOI: 10.1016/j.ophtha.2011.12.039. View

Otani T, Kishi S . Tomographic findings of foveal hard exudates in diabetic macular edema. Am J Ophthalmol. 2001; 131(1):50-4. DOI: 10.1016/s0002-9394(00)00661-9. View

Martidis A, Duker J, Greenberg P, Rogers A, Puliafito C, Reichel E . Intravitreal triamcinolone for refractory diabetic macular edema. Ophthalmology. 2002; 109(5):920-7. DOI: 10.1016/s0161-6420(02)00975-2. View

Massin P, Duguid G, Erginay A, Haouchine B, Gaudric A . Optical coherence tomography for evaluating diabetic macular edema before and after vitrectomy. Am J Ophthalmol. 2003; 135(2):169-77. DOI: 10.1016/s0002-9394(02)01837-8. View

Luttrull J, Dorin G . Subthreshold diode micropulse laser photocoagulation (SDM) as invisible retinal phototherapy for diabetic macular edema: a review. Curr Diabetes Rev. 2012; 8(4):274-84. PMC: 3412206. DOI: 10.2174/157339912800840523. View

Kempen J, OColmain B, Leske M, Haffner S, Klein R, Moss S . The prevalence of diabetic retinopathy among adults in the United States. Arch Ophthalmol. 2004; 122(4):552-63. DOI: 10.1001/archopht.122.4.552. View

Laursen M, Moeller F, Sander B, Sjoelie A . Subthreshold micropulse diode laser treatment in diabetic macular oedema. Br J Ophthalmol. 2004; 88(9):1173-9. PMC: 1772323. DOI: 10.1136/bjo.2003.040949. View

. Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study report number 1. Early Treatment Diabetic Retinopathy Study research group. Arch Ophthalmol. 1985; 103(12):1796-806. View

10.

Shahidi M, Wang Z, Zelkha R . Quantitative thickness measurement of retinal layers imaged by optical coherence tomography. Am J Ophthalmol. 2005; 139(6):1056-61. DOI: 10.1016/j.ajo.2005.01.012. View

11.

Bandello F, Polito A, Del Borrello M, Zemella N, Isola M . "Light" versus "classic" laser treatment for clinically significant diabetic macular oedema. Br J Ophthalmol. 2005; 89(7):864-70. PMC: 1772712. DOI: 10.1136/bjo.2004.051060. View

12.

Catier A, Tadayoni R, Paques M, Erginay A, Haouchine B, Gaudric A . Characterization of macular edema from various etiologies by optical coherence tomography. Am J Ophthalmol. 2005; 140(2):200-6. DOI: 10.1016/j.ajo.2005.02.053. View

13.

Ozdemir H, Karacorlu M, Karacorlu S . Regression of serous macular detachment after intravitreal triamcinolone acetonide in patients with diabetic macular edema. Am J Ophthalmol. 2005; 140(2):251-5. DOI: 10.1016/j.ajo.2005.03.004. View

14.

Chan A, Duker J, Ishikawa H, Ko T, Schuman J, Fujimoto J . Quantification of photoreceptor layer thickness in normal eyes using optical coherence tomography. Retina. 2006; 26(6):655-60. PMC: 1933486. DOI: 10.1097/01.iae.0000236468.33325.74. View

15.

Browning D, Glassman A, Aiello L, Beck R, Brown D, Fong D . Relationship between optical coherence tomography-measured central retinal thickness and visual acuity in diabetic macular edema. Ophthalmology. 2006; 114(3):525-36. PMC: 2585542. DOI: 10.1016/j.ophtha.2006.06.052. View

16.

Baba T, Yamamoto S, Arai M, Arai E, Sugawara T, Mitamura Y . Correlation of visual recovery and presence of photoreceptor inner/outer segment junction in optical coherence images after successful macular hole repair. Retina. 2008; 28(3):453-8. DOI: 10.1097/IAE.0b013e3181571398. View

17.

Srinivasan V, Monson B, Wojtkowski M, Bilonick R, Gorczynska I, Chen R . Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography. Invest Ophthalmol Vis Sci. 2008; 49(4):1571-9. PMC: 2846094. DOI: 10.1167/iovs.07-0838. View

18.

Aizawa S, Mitamura Y, Baba T, Hagiwara A, Ogata K, Yamamoto S . Correlation between visual function and photoreceptor inner/outer segment junction in patients with retinitis pigmentosa. Eye (Lond). 2008; 23(2):304-8. DOI: 10.1038/sj.eye.6703076. View

19.

Forooghian F, Stetson P, Meyer S, Chew E, Wong W, Cukras C . Relationship between photoreceptor outer segment length and visual acuity in diabetic macular edema. Retina. 2009; 30(1):63-70. PMC: 3021331. DOI: 10.1097/IAE.0b013e3181bd2c5a. View

20.

Nguyen Q, Shah S, Khwaja A, Channa R, Hatef E, Do D . Two-year outcomes of the ranibizumab for edema of the mAcula in diabetes (READ-2) study. Ophthalmology. 2010; 117(11):2146-51. DOI: 10.1016/j.ophtha.2010.08.016. View