Shedding Metabo'light' on the Search for Sepsis Biomarkers

Overview

Journal Crit Care

Specialty Critical Care

Date 2015 Jul 8

PMID 26148483

Citations 4

Authors

Claudia C Dos Santos

Affiliations

Soon will be listed here.

Abstract

The clinical presentation of severe infection with generalized inflammation is similar, if not identical, to systemic inflammation induced by sterile tissue injury. Novel models and unbiased technologies are urgently needed for biomarker identification and disease profiling in sepsis. Here we briefly review the article of Kamisoglu and colleagues in this issue of Critical Care on comparing metabolomics data from different studies to assess whether responses elicited by endotoxin recapitulate, at least in part, those seen in clinical sepsis.

Citing Articles

Prediction of sepsis mortality using metabolite biomarkers in the blood: a meta-analysis of death-related pathways and prospective validation.

Wang J, Sun Y, Teng S, Li K BMC Med. 2020; 18(1):83.

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NMR-Based Plasma Metabolomics at Set Intervals in Newborn Dairy Calves with Severe Sepsis.

Basoglu A, Sen I, Meoni G, Tenori L, Naseri A Mediators Inflamm. 2018; 2018:8016510.

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Urine metabolomics in neonates with late-onset sepsis in a case-control study.

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Serum concentrations of apoptosis-associated molecules in septic children with leukemia, neutropenia and fever.

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