Marine Peptides: Bioactivities and Applications

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2015 Jul 2

PMID 26132844

Citations 116

Authors

Randy Chi Fai Cheung

Tzi Bun Ng

Jack Ho Wong

Affiliations

Soon will be listed here.

Abstract

Peptides are important bioactive natural products which are present in many marine species. These marine peptides have high potential nutraceutical and medicinal values because of their broad spectra of bioactivities. Their antimicrobial, antiviral, antitumor, antioxidative, cardioprotective (antihypertensive, antiatherosclerotic and anticoagulant), immunomodulatory, analgesic, anxiolytic anti-diabetic, appetite suppressing and neuroprotective activities have attracted the attention of the pharmaceutical industry, which attempts to design them for use in the treatment or prevention of various diseases. Some marine peptides or their derivatives have high commercial values and had reached the pharmaceutical and nutraceutical markets. A large number of them are already in different phases of the clinical and preclinical pipeline. This review highlights the recent research in marine peptides and the trends and prospects for the future, with special emphasis on nutraceutical and pharmaceutical development into marketed products.

Citing Articles

Progress in Preparation Technology and Functional Research On Marine Bioactive Peptides.

Wang J, Li F, Li W, Li Y, Zhang J, Qin S Mar Biotechnol (NY). 2025; 27(1):42.

PMID: 39907808 DOI: 10.1007/s10126-024-10401-0.

Plant protein-derived anti-breast cancer peptides: sources, therapeutic approaches, mechanisms, and nanoparticle design.

Zhang D, Yuan Y, Zeng Q, Xiong J, Gan Y, Jiang K Front Pharmacol. 2025; 15:1468977.

PMID: 39898323 PMC: 11783187. DOI: 10.3389/fphar.2024.1468977.

Antimicrobial proteins from oyster hemolymph improve the efficacy of conventional antibiotics.

Summer K, Guo Q, Liu L, Barkla B, Giles S, Benkendorff K PLoS One. 2025; 20(1):e0312305.

PMID: 39836702 PMC: 11750097. DOI: 10.1371/journal.pone.0312305.

Plant and marine-derived natural products: sustainable pathways for future drug discovery and therapeutic development.

Ahmad M, Tahir M, Hong Z, Zia M, Rafeeq H, Ahmad M Front Pharmacol. 2025; 15():1497668.

PMID: 39834812 PMC: 11743463. DOI: 10.3389/fphar.2024.1497668.

Protective Effect of Marine Peptide from Against Gentamicin-Induced Hair Cell Damage in Zebrafish.

Zheng H, Zhu R, Zhang Y, Liu K, Xia Q, Li P Mar Drugs. 2024; 22(11).

PMID: 39590799 PMC: 11595687. DOI: 10.3390/md22110519.

References

Pelin M, Sosa S, Pacor S, Tubaro A, Florio C . The marine toxin palytoxin induces necrotic death in HaCaT cells through a rapid mitochondrial damage. Toxicol Lett. 2014; 229(3):440-50. DOI: 10.1016/j.toxlet.2014.07.022. View

da Costa J, Cova M, Ferreira R, Vitorino R . Antimicrobial peptides: an alternative for innovative medicines?. Appl Microbiol Biotechnol. 2015; 99(5):2023-40. DOI: 10.1007/s00253-015-6375-x. View

Luesch H, Moore R, Paul V, Mooberry S, Corbett T . Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1. J Nat Prod. 2001; 64(7):907-10. DOI: 10.1021/np010049y. View

Zhu C, Li G, Peng H, Zhang F, Chen Y, Li Y . Treatment with marine collagen peptides modulates glucose and lipid metabolism in Chinese patients with type 2 diabetes mellitus. Appl Physiol Nutr Metab. 2010; 35(6):797-804. DOI: 10.1139/H10-075. View

BERNHEIMER A, Avigad L, Lai C . Purification and properties of a toxin from the sea anemone Condylactis gigantea. Arch Biochem Biophys. 1982; 214(2):840-5. DOI: 10.1016/0003-9861(82)90091-1. View

Kouno K, Hirano S, Kuboki H, Kasai M, Hatae K . Effects of dried bonito (katsuobushi) and captopril, an angiotensin I-converting enzyme inhibitor, on rat isolated aorta: a possible mechanism of antihypertensive action. Biosci Biotechnol Biochem. 2005; 69(5):911-5. DOI: 10.1271/bbb.69.911. View

Waters A, Hill R, Place A, Hamann M . The expanding role of marine microbes in pharmaceutical development. Curr Opin Biotechnol. 2010; 21(6):780-6. PMC: 2994104. DOI: 10.1016/j.copbio.2010.09.013. View

Goldwasser F, Faivre S, Alexandre J, Coronado C, Fernandez-Garcia E, Kahatt C . Phase I study of elisidepsin (Irvalec®) in combination with carboplatin or gemcitabine in patients with advanced malignancies. Invest New Drugs. 2014; 32(3):500-9. DOI: 10.1007/s10637-013-0060-7. View

Edelman M, Gandara D, Hausner P, Israel V, Thornton D, DeSanto J . Phase 2 study of cryptophycin 52 (LY355703) in patients previously treated with platinum based chemotherapy for advanced non-small cell lung cancer. Lung Cancer. 2003; 39(2):197-9. DOI: 10.1016/s0169-5002(02)00511-1. View

10.

Bendell J, Saleh M, Rose A, Siegel P, Hart L, Sirpal S . Phase I/II study of the antibody-drug conjugate glembatumumab vedotin in patients with locally advanced or metastatic breast cancer. J Clin Oncol. 2014; 32(32):3619-25. DOI: 10.1200/JCO.2013.52.5683. View

11.

Ferreira S, Bartelt D, Greene L . Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom. Biochemistry. 1970; 9(13):2583-93. DOI: 10.1021/bi00815a005. View

12.

Cudennec B, Ravallec R . Biological active peptides from marine sources related to gut hormones. Curr Protein Pept Sci. 2013; 14(3):231-4. DOI: 10.2174/13892037113149990034. View

13.

Jheng Y, Lee L, Ting C, Pan C, Hui C, Chen J . Zebrafish fed on recombinant Artemia expressing epinecidin-1 exhibit increased survival and altered expression of immunomodulatory genes upon Vibrio vulnificus infection. Fish Shellfish Immunol. 2014; 42(1):1-15. DOI: 10.1016/j.fsi.2014.10.019. View

14.

Mayer A, Rodriguez A, Taglialatela-Scafati O, Fusetani N . Marine pharmacology in 2009-2011: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous.... Mar Drugs. 2013; 11(7):2510-73. PMC: 3736438. DOI: 10.3390/md11072510. View

15.

Smith C, Zhang X, Mooberry S, Patterson G, Moore R . Cryptophycin: a new antimicrotubule agent active against drug-resistant cells. Cancer Res. 1994; 54(14):3779-84. View

16.

Butterfield D, Drake J, Pocernich C, Castegna A . Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide. Trends Mol Med. 2001; 7(12):548-54. DOI: 10.1016/s1471-4914(01)02173-6. View

17.

Gur Barzilai M, Kahn R, Regev N, Gordon D, Moran Y, Gurevitz M . The specificity of Av3 sea anemone toxin for arthropods is determined at linker DI/SS2-S6 in the pore module of target sodium channels. Biochem J. 2014; 463(2):271-7. DOI: 10.1042/BJ20140576. View

18.

Sukhan Z, Kitano H, Selvaraj S, Yoneda M, Yamaguchi A, Matsuyama M . Identification and distribution of three gonadotropin-releasing hormone (GnRH) isoforms in the brain of a clupeiform fish, Engraulis japonicus. Zoolog Sci. 2013; 30(12):1081-91. DOI: 10.2108/zsj.30.1081. View

19.

Howard A, Udenigwe C . Mechanisms and prospects of food protein hydrolysates and peptide-induced hypolipidaemia. Food Funct. 2012; 4(1):40-51. DOI: 10.1039/c2fo30216k. View

20.

Bauer A, Bronstrup M . Industrial natural product chemistry for drug discovery and development. Nat Prod Rep. 2013; 31(1):35-60. DOI: 10.1039/c3np70058e. View