Spatial Moran Models, II: Cancer Initiation in Spatially Structured Tissue

Overview

Journal J Math Biol

Date 2015 Jul 2

PMID 26126947

Citations 16

Authors

R Durrett

J Foo

K Leder

Affiliations

Soon will be listed here.

Abstract

We study the accumulation and spread of advantageous mutations in a spatial stochastic model of cancer initiation on a lattice. The parameters of this general model can be tuned to study a variety of cancer types and genetic progression pathways. This investigation contributes to an understanding of how the selective advantage of cancer cells together with the rates of mutations driving cancer, impact the process and timing of carcinogenesis. These results can be used to give insights into tumor heterogeneity and the "cancer field effect," the observation that a malignancy is often surrounded by cells that have undergone premalignant transformation.

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