Cancer in Light of Experimental Evolution

Overview

Journal Curr Biol

Publisher Cell Press

Specialty Biology

Date 2012 Sep 15

PMID 22975007

Citations 49

Authors

Kathleen Sprouffske

Lauren M F Merlo

Philip J Gerrish

Carlo C Maley

Paul D Sniegowski

Affiliations

Soon will be listed here.

Abstract

Cancer initiation, progression, and the emergence of therapeutic resistance are evolutionary phenomena of clonal somatic cell populations. Studies in microbial experimental evolution and the theoretical work inspired by such studies are yielding deep insights into the evolutionary dynamics of clonal populations, yet there has been little explicit consideration of the relevance of this rapidly growing field to cancer biology. Here, we examine how the understanding of mutation, selection, and spatial structure in clonal populations that is emerging from experimental evolution may be applicable to cancer. Along the way, we discuss some significant ways in which cancer differs from the model systems used in experimental evolution. Despite these differences, we argue that enhanced prediction and control of cancer may be possible using ideas developed in the context of experimental evolution, and we point out some prospects for future research at the interface between these traditionally separate areas.

Citing Articles

Unravelling the Complexity of Colorectal Cancer: Heterogeneity, Clonal Evolution, and Clinical Implications.

Saoudi Gonzalez N, Salva F, Ros J, Baraibar I, Rodriguez-Castells M, Garcia A Cancers (Basel). 2023; 15(16).

PMID: 37627048 PMC: 10452468. DOI: 10.3390/cancers15164020.

Adaptation in Outbred Sexual Yeast is Repeatable, Polygenic and Favors Rare Haplotypes.

Linder R, Zabanavar B, Majumder A, Hoang H, Delgado V, Tran R Mol Biol Evol. 2022; 39(12).

PMID: 36366952 PMC: 9728589. DOI: 10.1093/molbev/msac248.

Population genetics of clonally transmissible cancers.

Ni Leathlobhair M, Lenski R Nat Ecol Evol. 2022; 6(8):1077-1089.

PMID: 35879542 DOI: 10.1038/s41559-022-01790-3.

Temporal evolution of master regulator Crp identifies pyrimidines as catabolite modulator factors.

Lauritsen I, Frendorf P, Capucci S, Heyde S, Blomquist S, Wendel S Nat Commun. 2021; 12(1):5880.

PMID: 34620864 PMC: 8497467. DOI: 10.1038/s41467-021-26098-x.

Stochastic gene expression drives mesophyll protoplast regeneration.

Xu M, Du Q, Tian C, Wang Y, Jiao Y Sci Adv. 2021; 7(33).

PMID: 34380624 PMC: 8357238. DOI: 10.1126/sciadv.abg8466.

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