Downregulation of MiR-410 Targeting the Cyclin B1 Gene Plays a Role in Pituitary Gonadotroph Tumors

Overview

Journal Cell Cycle

Specialty Cell Biology

Date 2015 Jul 1

PMID 26125663

Citations 29

Authors

Paula Mussnich

Gerald Raverot

Marie-Lise Jaffrain-Rea

Filippo Fraggetta

Anne Wierinckx

Jacqueline Trouillas

Alfredo Fusco

Daniela DAngelo

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that act as posttranscriptional regulators of gene expression, and are frequently altered in human neoplasias. Here, we have analyzed the miRNA expression profile of human gonadotroph adenomas versus normal pituitary tissue using a miRNACHIP microarray. We demonstrate that miRNA-410 is downregulated in gonadotroph adenomas when compared with normal pituitary gland. We validate CCNB1 as target of miRNA-410 since its overexpression reduces CCNB1 at protein and mRNA levels, decreasing cell proliferation. In conclusion, our study suggess that the downregulation of miRNA-410 plays a role in the behavior of gonadotroph tumors.

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