A Dual Wavelength-activatable Gold Nanorod Complex for Synergistic Cancer Treatment

Overview

Journal Nanoscale

Specialty Biotechnology

Date 2015 Jul 1

PMID 26122945

Citations 6

Authors

Dennis B Pacardo

Bhanu Neupane

S Michaela Rikard

Yue Lu

Ran Mo

Sumeet R Mishra

Joseph B Tracy

Gufeng Wang

Frances S Ligler

Zhen Gu

Affiliations

Soon will be listed here.

Abstract

A multifunctional gold nanorod (AuNR) complex is described with potential utility for theranostic anticancer treatment. The AuNR was functionalized with cyclodextrin for encapsulation of doxorubicin, with folic acid for targeting, and with a photo-responsive dextran-azo compound for intracellular controlled drug release. The interaction of a AuNR complex with HeLa cells was facilitated via a folic acid targeting ligand as displayed in the dark-field images of cells. Enhanced anticancer efficacy was demonstrated through the synergistic combination of promoted drug release upon ultraviolet (UV) light irradiation and photothermal therapy upon infrared (IR) irradiation. This multifunctional AuNR-based system represents a novel theranostic strategy for spatiotemporal delivery of anticancer therapeutics.

Citing Articles

Engineering Gold Nanostructures for Cancer Treatment: Spherical Nanoparticles, Nanorods, and Atomically Precise Nanoclusters.

He W, Ma G, Shen Q, Tang Z Nanomaterials (Basel). 2022; 12(10).

PMID: 35630959 PMC: 9146553. DOI: 10.3390/nano12101738.

NIR Stimulus-Responsive PdPt Bimetallic Nanoparticles for Drug Delivery and Chemo-Photothermal Therapy.

Chu C, Bao Z, Sun M, Wang X, Zhang H, Chen W Pharmaceutics. 2020; 12(7).

PMID: 32709022 PMC: 7408621. DOI: 10.3390/pharmaceutics12070675.

Albumin-bioinspired iridium oxide nanoplatform with high photothermal conversion efficiency for synergistic chemo-photothermal of osteosarcoma.

Gu W, Zhang T, Gao J, Wang Y, Li D, Zhao Z Drug Deliv. 2019; 26(1):918-927.

PMID: 31526064 PMC: 6758616. DOI: 10.1080/10717544.2019.1662513.

AlPcS-PDT for gastric cancer therapy using gold nanorod, cationic liposome, and Pluronic F127 nanomicellar drug carriers.

Xin J, Wang S, Wang B, Wang J, Wang J, Zhang L Int J Nanomedicine. 2018; 13:2017-2036.

PMID: 29670347 PMC: 5894760. DOI: 10.2147/IJN.S154054.

D-alanyl-D-alanine-Modified Gold Nanoparticles Form a Broad-Spectrum Sensor for Bacteria.

Yang X, Dang Y, Lou J, Shao H, Jiang X Theranostics. 2018; 8(5):1449-1457.

PMID: 29507633 PMC: 5835949. DOI: 10.7150/thno.22540.

References

Wang S, Chen K, Wu T, Wang H, Lin W, Ohashi M . Photothermal effects of supramolecularly assembled gold nanoparticles for the targeted treatment of cancer cells. Angew Chem Int Ed Engl. 2010; 49(22):3777-81. PMC: 2892041. DOI: 10.1002/anie.201000062. View

Huang X, El-Sayed I, Qian W, El-Sayed M . Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. J Am Chem Soc. 2006; 128(6):2115-20. DOI: 10.1021/ja057254a. View

Sau T, Murphy C . Seeded high yield synthesis of short Au nanorods in aqueous solution. Langmuir. 2004; 20(15):6414-20. DOI: 10.1021/la049463z. View

Pacardo D, Neupane B, Wang G, Gu Z, Walker G, Ligler F . A temperature microsensor for measuring laser-induced heating in gold nanorods. Anal Bioanal Chem. 2014; 407(3):719-25. DOI: 10.1007/s00216-014-8222-9. View

Guo R, Zhang L, Qian H, Li R, Jiang X, Liu B . Multifunctional nanocarriers for cell imaging, drug delivery, and near-IR photothermal therapy. Langmuir. 2010; 26(8):5428-34. DOI: 10.1021/la903893n. View

Giljohann D, Seferos D, Daniel W, Massich M, Patel P, Mirkin C . Gold nanoparticles for biology and medicine. Angew Chem Int Ed Engl. 2010; 49(19):3280-94. PMC: 3930332. DOI: 10.1002/anie.200904359. View

Dreaden E, Alkilany A, Huang X, Murphy C, El-Sayed M . The golden age: gold nanoparticles for biomedicine. Chem Soc Rev. 2011; 41(7):2740-79. PMC: 5876014. DOI: 10.1039/c1cs15237h. View

Smith A, Duan H, Mohs A, Nie S . Bioconjugated quantum dots for in vivo molecular and cellular imaging. Adv Drug Deliv Rev. 2008; 60(11):1226-1240. PMC: 2649798. DOI: 10.1016/j.addr.2008.03.015. View

Saul J, Annapragada A, Natarajan J, Bellamkonda R . Controlled targeting of liposomal doxorubicin via the folate receptor in vitro. J Control Release. 2003; 92(1-2):49-67. DOI: 10.1016/s0168-3659(03)00295-5. View

10.

Xu H, Cheng L, Wang C, Ma X, Li Y, Liu Z . Polymer encapsulated upconversion nanoparticle/iron oxide nanocomposites for multimodal imaging and magnetic targeted drug delivery. Biomaterials. 2011; 32(35):9364-73. DOI: 10.1016/j.biomaterials.2011.08.053. View

11.

Hughes G . Nanostructure-mediated drug delivery. Nanomedicine. 2007; 1(1):22-30. DOI: 10.1016/j.nano.2004.11.009. View

12.

Chen Y, Pang Y, Wu J, Su Y, Liu J, Wang R . Controlling the particle size of interpolymer complexes through host-guest interaction for drug delivery. Langmuir. 2010; 26(11):9011-6. DOI: 10.1021/la9048133. View

13.

Kostarelos K, Bianco A, Prato M . Promises, facts and challenges for carbon nanotubes in imaging and therapeutics. Nat Nanotechnol. 2009; 4(10):627-33. DOI: 10.1038/nnano.2009.241. View

14.

Peer D, Karp J, Hong S, Farokhzad O, Margalit R, Langer R . Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol. 2008; 2(12):751-60. DOI: 10.1038/nnano.2007.387. View

15.

Boisselier E, Astruc D . Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity. Chem Soc Rev. 2009; 38(6):1759-82. DOI: 10.1039/b806051g. View

16.

Xiao Z, Ji C, Shi J, Pridgen E, Frieder J, Wu J . DNA self-assembly of targeted near-infrared-responsive gold nanoparticles for cancer thermo-chemotherapy. Angew Chem Int Ed Engl. 2012; 51(47):11853-7. PMC: 3532659. DOI: 10.1002/anie.201204018. View

17.

Alkilany A, Thompson L, Boulos S, Sisco P, Murphy C . Gold nanorods: their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions. Adv Drug Deliv Rev. 2011; 64(2):190-9. DOI: 10.1016/j.addr.2011.03.005. View

18.

Tasciotti E, Liu X, Bhavane R, Plant K, Leonard A, Price B . Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications. Nat Nanotechnol. 2008; 3(3):151-7. DOI: 10.1038/nnano.2008.34. View

19.

Huang X, Neretina S, El-Sayed M . Gold nanorods: from synthesis and properties to biological and biomedical applications. Adv Mater. 2014; 21(48):4880-4910. DOI: 10.1002/adma.200802789. View

20.

Sun T, Du J, Yao Y, Mao C, Dou S, Huang S . Simultaneous delivery of siRNA and paclitaxel via a "two-in-one" micelleplex promotes synergistic tumor suppression. ACS Nano. 2011; 5(2):1483-94. DOI: 10.1021/nn103349h. View