Time-efficient, High-resolution, Whole Brain Three-dimensional Macromolecular Proton Fraction Mapping

Overview

Journal Magn Reson Med

Publisher Wiley

Specialty Radiology

Date 2015 Jun 24

PMID 26102097

Citations 39

Authors

Vasily L Yarnykh

Affiliations

Soon will be listed here.

Abstract

Purpose: Macromolecular proton fraction (MPF) mapping is a quantitative MRI method that reconstructs parametric maps of a relative amount of macromolecular protons causing the magnetization transfer (MT) effect and provides a biomarker of myelination in neural tissues. This study aimed to develop a high-resolution whole brain MPF mapping technique using a minimal number of source images for scan time reduction.

Methods: The described technique was based on replacement of an actually acquired reference image without MT saturation by a synthetic one reconstructed from R1 and proton density maps, thus requiring only three source images. This approach enabled whole brain three-dimensional MPF mapping with isotropic 1.25 × 1.25 × 1.25 mm(3) voxel size and a scan time of 20 min. The synthetic reference method was validated against standard MPF mapping with acquired reference images based on data from eight healthy subjects.

Results: Mean MPF values in segmented white and gray matter appeared in close agreement with no significant bias and small within-subject coefficients of variation (<2%). High-resolution MPF maps demonstrated sharp white-gray matter contrast and clear visualization of anatomical details, including gray matter structures with high iron content.

Conclusions: The proposed synthetic reference method improves resolution of MPF mapping and combines accurate MPF measurements with unique neuroanatomical contrast features.

Citing Articles

Quantitative magnetization transfer and g-ratio imaging of white matter myelin in early psychotic spectrum disorders.

Sui Y, Bertisch H, Goff D, Samsonov A, Lazar M Mol Psychiatry. 2025; .

PMID: 39779900 DOI: 10.1038/s41380-024-02883-0.

Global and Regional Sex-Related Differences, Asymmetry, and Peak Age of Brain Myelination in Healthy Adults.

Khodanovich M, Svetlik M, Naumova A, Usova A, Pashkevich V, Moshkina M J Clin Med. 2024; 13(23).

PMID: 39685523 PMC: 11642669. DOI: 10.3390/jcm13237065.

Single-point macromolecular proton fraction mapping using a 0.3 T permanent magnet MRI system: phantom and healthy volunteer study.

Fujiwara Y, Eitoku S, Sakae N, Izumi T, Kumazoe H, Kitajima M Radiol Phys Technol. 2024; 17(4):869-877.

PMID: 39251498 DOI: 10.1007/s12194-024-00843-5.

Demyelination in Patients with POST-COVID Depression.

Khodanovich M, Svetlik M, Kamaeva D, Usova A, Kudabaeva M, Ananina T J Clin Med. 2024; 13(16).

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Spin-lock based fast whole-brain 3D macromolecular proton fraction mapping of relapsing-remitting multiple sclerosis.

Hou J, Cai Z, Chen W, So T Sci Rep. 2024; 14(1):17943.

PMID: 39095418 PMC: 11297137. DOI: 10.1038/s41598-024-67445-4.

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