MicroRNA-219-5p Exerts Tumor Suppressor Function by Targeting ROBO1 in Glioblastoma

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2015 Jun 18

PMID 26081620

Citations 15

Authors

Yongmei Jiang

Lin Yin

Huirong Jing

Hui Zhang

Affiliations

Soon will be listed here.

Abstract

Previous studies have shown that miR-219-5p is dysregulated and exerts tumor-suppressive effects in cancer development and progression. However, the molecular function and mechanism of miR-219-5p in glioblastoma growth and invasion are still unclear. In the present study, we show that miR-219-5p was downregulated in a panel of glioma tissues with different grades and in all the human glioma cell lines examined. Ectopic expression of miR-219-5p inhibited proliferation and invasion and induced apoptosis in vitro, and xenograft formation in vivo. ROBO1 was found to be a direct target of miR-219-5p, and when overexpressed in miR-219-5p-expressing glioma cells, was able to restore proliferative and invasive ability. Finally, in vivo investigation confirmed that miR-219-5p was a tumor suppressor that regulated ROBO1 expression. Taken together, these studies demonstrate that miR-219-5p inhibited cancer cell growth and invasion by direct targeting ROBO1, implicating miR-219-5p as an attractive candidate for cancer therapy.

Citing Articles

MicroRNA-219 in the central nervous system: a potential theranostic approach.

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microRNA-219-5p targets NEK6 to inhibit hepatocellular carcinoma progression.

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MicroRNA-219-5p participates in cyanotic congenital heart disease progression by regulating cardiomyocyte apoptosis.

Hu C, Huang S, Wu F, Ding H Exp Ther Med. 2020; 21(1):36.

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MicroRNA Profile Identifies miR-6165 Could Suppress Gastric Cancer Migration and Invasion by Targeting STRN4.

Wang Z, Li Y, Cao J, Zhang W, Wang Q, Zhang Z Onco Targets Ther. 2020; 13:1859-1869.

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