MicroRNAs Involved in Chemo- and Radioresistance of High-grade Gliomas

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2013 Apr 10

PMID 23568705

Citations 26

Authors

Andrej Besse

Jiri Sana

Pavel Fadrus

Ondrej Slaby

Affiliations

Soon will be listed here.

Abstract

High-grade gliomas (HGGs) are malignant primary brain tumors of glial cell origin. Despite optimal course of treatment, including maximal surgical resection followed by adjuvant chemo- and/or radiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo- and radioresistance of these tumors. In recent years, several signaling pathways, especially PI3K/AKT and ATM/CHK2/p53, have been linked to the resistance of gliomas. Moreover, additional studies have shown that these pathways are significantly regulated by microRNAs (miRNAs), short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis, proliferation, cell cycle, invasivity, and angiogenesis. MiRNAs are not only highly deregulated in gliomas, their expression signatures have also been shown to predict prognosis and therapy response. Therefore, they present promising biomarkers and therapeutic targets that might overcome the resistance to treatment and improve prognosis of glioma patients. In this review, we summarize the current knowledge of the functional role of miRNAs in gliomas resistance to chemo- and radiotherapy.

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References

Wang J, Wakeman T, Lathia J, Hjelmeland A, Wang X, White R . Notch promotes radioresistance of glioma stem cells. Stem Cells. 2009; 28(1):17-28. PMC: 2825687. DOI: 10.1002/stem.261. View

Shi L, Zhang J, Pan T, Zhou J, Gong W, Liu N . MiR-125b is critical for the suppression of human U251 glioma stem cell proliferation. Brain Res. 2009; 1312:120-6. DOI: 10.1016/j.brainres.2009.11.056. View

Li W, Ma M, Dong L, Wang F, Chen L, Li X . MicroRNA-34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme. Cancer Biol Ther. 2011; 12(6):477-83. DOI: 10.4161/cbt.12.6.16300. View

Shi L, Chen J, Yang J, Pan T, Zhang S, Wang Z . MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity. Brain Res. 2010; 1352:255-64. DOI: 10.1016/j.brainres.2010.07.009. View

Zhang W, Zhang J, Hoadley K, Kushwaha D, Ramakrishnan V, Li S . miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression. Neuro Oncol. 2012; 14(6):712-9. PMC: 3367855. DOI: 10.1093/neuonc/nos089. View

van den Bent M . Anaplastic oligodendroglioma and oligoastrocytoma. Neurol Clin. 2007; 25(4):1089-109, ix-x. DOI: 10.1016/j.ncl.2007.07.013. View

Squatrito M, Brennan C, Helmy K, Huse J, Petrini J, Holland E . Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas. Cancer Cell. 2010; 18(6):619-29. PMC: 3818087. DOI: 10.1016/j.ccr.2010.10.034. View

Xu X, Wang X, Chen M, Liu T, Li Y, Jia W . RETRACTED: MicroRNA-19a and -19b regulate cervical carcinoma cell proliferation and invasion by targeting CUL5. Cancer Lett. 2012; 322(2):148-58. DOI: 10.1016/j.canlet.2012.02.038. View

Carmo A, Carvalheiro H, Crespo I, Nunes I, Lopes M . Effect of temozolomide on the U-118 glioma cell line. Oncol Lett. 2012; 2(6):1165-1170. PMC: 3406512. DOI: 10.3892/ol.2011.406. View

10.

Fell V, Schild-Poulter C . Ku regulates signaling to DNA damage response pathways through the Ku70 von Willebrand A domain. Mol Cell Biol. 2011; 32(1):76-87. PMC: 3255697. DOI: 10.1128/MCB.05661-11. View

11.

Liu M, Wang Z, Yang S, Zhang W, He S, Hu C . TNF-α is a novel target of miR-19a. Int J Oncol. 2011; 38(4):1013-22. DOI: 10.3892/ijo.2011.924. View

12.

Zhou X, Ren Y, Moore L, Mei M, You Y, Xu P . Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status. Lab Invest. 2010; 90(2):144-55. DOI: 10.1038/labinvest.2009.126. View

13.

Rajaraman P, Melin B, Wang Z, McKean-Cowdin R, Michaud D, Wang S . Genome-wide association study of glioma and meta-analysis. Hum Genet. 2012; 131(12):1877-88. PMC: 3761216. DOI: 10.1007/s00439-012-1212-0. View

14.

Chen L, Zhang J, Han L, Zhang A, Zhang C, Zheng Y . Downregulation of miR-221/222 sensitizes glioma cells to temozolomide by regulating apoptosis independently of p53 status. Oncol Rep. 2011; 27(3):854-60. DOI: 10.3892/or.2011.1535. View

15.

Nan Y, Han L, Zhang A, Wang G, Jia Z, Yang Y . MiRNA-451 plays a role as tumor suppressor in human glioma cells. Brain Res. 2010; 1359:14-21. DOI: 10.1016/j.brainres.2010.08.074. View

16.

Li Y, Guessous F, Zhang Y, diPierro C, Kefas B, Johnson E . MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res. 2009; 69(19):7569-76. PMC: 2756313. DOI: 10.1158/0008-5472.CAN-09-0529. View

17.

Godlewski J, Nowicki M, Bronisz A, Williams S, Otsuki A, Nuovo G . Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res. 2008; 68(22):9125-30. DOI: 10.1158/0008-5472.CAN-08-2629. View

18.

Le M, Teh C, Shyh-Chang N, Xie H, Zhou B, Korzh V . MicroRNA-125b is a novel negative regulator of p53. Genes Dev. 2009; 23(7):862-76. PMC: 2666337. DOI: 10.1101/gad.1767609. View

19.

Yamada R, Nakano I . Glioma stem cells: their role in chemoresistance. World Neurosurg. 2012; 77(2):237-40. DOI: 10.1016/j.wneu.2012.01.004. View

20.

Srinivasan S, Patric I, Somasundaram K . A ten-microRNA expression signature predicts survival in glioblastoma. PLoS One. 2011; 6(3):e17438. PMC: 3069027. DOI: 10.1371/journal.pone.0017438. View