Association of Hypertension and Obesity with Renal Cell Carcinoma Risk: a Report from the Shanghai Men's and Women's Health Studies

Overview

Journal Cancer Causes Control

Specialties Oncology
Public Health

Date 2015 Jun 18

PMID 26081424

Citations 16

Authors

Tian Shen

Xiao-Ou Shu

Yong-Bing Xiang

Hong-Lan Li

Hui Cai

Yu-Tang Gao

Wei Zheng

Loren Lipworth

Affiliations

Soon will be listed here.

Abstract

Purpose: Consistently reported associations between hypertension and obesity and renal cell carcinoma (RCC) risk have largely come from studies in Western populations. These associations were examined in a case-control study nested in the Shanghai Women's Health Study (SWHS, 1996-2000) and Shanghai Men's Health Study (SMHS, 2001-2006).

Methods: Overall, 271 incident RCC cases (124 women, 147 men) were identified through 31 December 2011, and 2,693 controls were individually matched by sex, age, and calendar time at cohort enrollment, and menopausal status (for women). Participants completed a structured questionnaire by in-person interview at baseline, and conditional logistic regression was used to estimate odds ratios (ORs) and 95 % confidence intervals (CIs).

Results: Self-reported hypertension was associated with a significant 40 % increased risk of RCC among women and men (95 % CI 1.1, 1.9). Body mass index (BMI), modeled continuously, was associated with an elevated risk of RCC among men, with an OR of 1.5 (95 % CI 1.1, 2.0) per 5 kg/m(2) increase in BMI, but not among women.

Conclusions: Hypertension is independently associated with risk of RCC among both women and men in Shanghai, while overweight and obesity appear to be associated with risk of RCC in Chinese men only.

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