The Characteristics of Antioxidant Activity After Liver Transplantation in Biliary Atresia Patients

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2015 Jun 12

PMID 26064908

Citations 4

Authors

Chih-Jen Chen

Kuo-Shu Tang

Ying-Hsien Huang

Chao-Long Chen

Li-Tung Huang

Jiin-Haur Chuang

Mao-Meng Tiao

Affiliations

Soon will be listed here.

Abstract

Purpose: Cholestatic liver injury is associated with a high production of free radicals. The pathogenesis of liver injury in biliary atresia (BA) patients is largely undefined. The goal of the present study was to clarify the oxidative damage and the changes in antioxidant enzyme activities that occur during the development of BA and after liver transplantation (LT).

Methods: We enrolled BA patients and control subjects and collected their clinical information. The activities of antioxidant enzymes in BA patients before LT (BA group) and after LT (LT group) were analyzed.

Results: The number of mitochondrial DNA copies had increased in the LT group compared with the BA group. Similarly, the activity of glutathione peroxidase had increased in the LT group compared with the BA group. The level of glutathione was higher in the LT group than in the BA group. Malondialdehyde levels were decreased in the LT group compared with the BA group.

Conclusions: These data indicate that LT is associated with increased antioxidant enzyme activities and decreased malondialdehyde levels in BA patients. The manipulation of mitochondria-associated antioxidative activity might be an important future management strategy for BA.

Citing Articles

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