Regulation of Bile Duct Epithelial Injury by Hepatic CD71+ Erythroid Cells

Overview

Journal JCI Insight

Specialties Biomedical Engineering
General Medicine

Date 2020 May 15

PMID 32407296

Citations 10

Authors

Li Yang

Pranavkumar Shivakumar

Jeremy Kinder

Sing Sing Way

Bryan Donnelly

Reena Mourya

Zhenhua Luo

Jorge A Bezerra

Affiliations

Soon will be listed here.

Abstract

Extramedullary hematopoietic cells are present in the liver of normal neonates in the first few days of life and persist in infants with biliary atresia. Based on a previous report that liver genes are enriched by erythroid pathways, we examined the liver gene expression pattern at diagnosis and found the top 5 enriched pathways are related to erythrocyte pathobiology in children who survived with the native liver beyond 2 years of age. Using immunostaining, anti-CD71 antibodies identified CD71+ erythroid cells among extramedullary hematopoietic cells in the livers at the time of diagnosis. In mechanistic experiments, the preemptive antibody depletion of hepatic CD71+ erythroid cells in neonatal mice rendered them resistant to rhesus rotavirus-induced (RRV-induced) biliary atresia. The depletion of CD71+ erythroid cells increased the number of effector lymphocytes and delayed the RRV infection of livers and extrahepatic bile ducts. In coculture experiments, CD71+ erythroid cells suppressed the activation of hepatic mononuclear cells. These data uncover an immunoregulatory role for CD71+ erythroid cells in the neonatal liver.

Citing Articles

Immunoregulation role of the erythroid cells.

Niu C, Zhang J Front Immunol. 2024; 15:1466669.

PMID: 39474425 PMC: 11518727. DOI: 10.3389/fimmu.2024.1466669.

Long non-coding RNA growth arrest-specific 5 inhibits liver fibrogenesis in biliary atresia by interacting with microRNA-222 and repressing IGF1/AKT signaling.

Wang R, Gao Y Transl Pediatr. 2024; 12(12):2107-2120.

PMID: 38197105 PMC: 10772835. DOI: 10.21037/tp-23-424.

CD71 erythroid cells suppress T-cell effector functions and predict immunotherapy outcomes in patients with virus-associated solid tumors.

Bozorgmehr N, Okoye I, Mashhouri S, Lu J, Koleva P, Walker J J Immunother Cancer. 2023; 11(5).

PMID: 37236637 PMC: 10230995. DOI: 10.1136/jitc-2022-006595.

The role of erythrocytes and erythroid progenitor cells in tumors.

Zhang H, Wan G, Wang Y, Chen W, Guan J Open Life Sci. 2022; 17(1):1641-1656.

PMID: 36567722 PMC: 9755711. DOI: 10.1515/biol-2022-0102.

Single-cell transcriptomic analysis identifies an immune-prone population in erythroid precursors during human ontogenesis.

Xu C, He J, Wang H, Zhang Y, Wu J, Zhao L Nat Immunol. 2022; 23(7):1109-1120.

PMID: 35761081 DOI: 10.1038/s41590-022-01245-8.

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