Total Artificial Hearts: Past, Present, and Future

Overview

Journal Nat Rev Cardiol

Specialty Cardiology & Vascular Diseases

Date 2015 Jun 3

PMID 26031698

Citations 11

Authors

William E Cohn

Daniel L Timms

O H Frazier

Affiliations

Soon will be listed here.

Abstract

A practical artificial heart has been sought for >50 years. An increasing number of people succumb to heart disease each year, but the number of hearts available for transplantation remains small. Early total artificial hearts mimicked the pumping action of the native heart. These positive-displacement pumps could provide adequate haemodynamic support and maintain the human circulation for short periods, but large size and limited durability adversely affected recipients' quality of life. Subsequent research into left ventricular assist devices led to the use of continuous-flow blood pumps with rotating impellers. Researchers have attempted to integrate this technology into modern total artificial hearts with moderate clinical success. The importance of pulsatile circulation remains unclear. Future research is, therefore, needed into positive-displacement and rotary total artificial hearts.

Citing Articles

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