HIV Therapeutic Vaccines: Moving Towards a Functional Cure

Overview

Journal Curr Opin Immunol

Publisher Elsevier

Specialty Allergy & Immunology

Date 2015 May 22

PMID 25996629

Citations 33

Authors

Geetha H Mylvaganam

Guido Silvestri

Rama Rao Amara

Affiliations

Soon will be listed here.

Abstract

Anti-viral T-cell and B-cell responses play a crucial role in suppressing HIV and SIV replication during chronic infection. However, these infections are rarely controlled by the host immune response, and most infected individuals need lifelong antiretroviral therapy (ART). Recent advances in our understanding of how anti-HIV immune responses are elicited and regulated prompted a surge of interest in harnessing these responses to reduce the HIV 'residual disease' that is present in ART-treated HIV-infected individuals. Novel approaches that are currently explored include both conventional therapeutic vaccines (i.e., active immunization strategies using HIV-derived immunogens) as well as the use of checkpoint blockers such as anti-PD-1 antibodies. These approaches appear promising as key components of complex therapeutic strategies aimed at curing HIV infection.

Citing Articles

Identification of antibody targets associated with lower HIV viral load and viremic control.

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Decoupling HIV-1 antiretroviral drug inhibition from plasma antibody activity to evaluate broadly neutralizing antibody therapeutics and vaccines.

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New Approaches to Dendritic Cell-Based Therapeutic Vaccines Against HIV-1 Infection.

Espinar-Buitrago M, Munoz-Fernandez M Front Immunol. 2022; 12:719664.

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Protection against SIV in Rhesus Macaques Using Albumin and CD4-Based Vector-Mediated Gene Transfer.

Spitsin S, Schnepp B, Connell M, Liu T, Dang C, Pappa V Mol Ther Methods Clin Dev. 2020; 17:1088-1096.

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