Is the Neutrophil to Lymphocyte Ratio Associated with Liver Fibrosis in Patients with Chronic Hepatitis B?

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2015 May 20

PMID 25987782

Citations 9

Authors

Murat Kekilli

Alpaslan Tanoglu

Yusuf Serdar Sakin

Mevlut Kurt

Serkan Ocal

Sait Bagci

Affiliations

Soon will be listed here.

Abstract

Aim: To determine the association between the neutrophil to lymphocyte (N/L) ratio and the degree of liver ﬁbrosis in patients with chronic hepatitis B (CHB) infection.

Methods: Between December 2011 and February 2013, 129 consecutive CHB patients who were admitted to the study hospitals for histological evaluation of chronic hepatitis B-related liver ﬁbrosis were included in this retrospective study. The patients were divided into two groups based on the fibrosis score: individuals with a fibrosis score of F0 or F1 were included in the "no/minimal liver fibrosis" group, whereas patients with a fibrosis score of F2, F3, or F4 were included in the "advanced liver fibrosis" group. The Statistical Package for Social Sciences 18.0 for Windows was used to analyze the data. A P value of < 0.05 was accepted as statistically significant.

Results: Three experienced and blinded pathologists evaluated the ﬁbrotic status and inﬂammatory activity of 129 liver biopsy samples from the CHB patients. Following histopathological examination, the "no/minimal fibrosis" group included 79 individuals, while the "advanced fibrosis" group included 50 individuals. Mean (N/L) ratio levels were notably lower in patients with advanced fibrosis when compared with patients with no/minimal fibrosis. The mean value of the aspartate aminotransferase-platelet ratio index was markedly higher in cases with advanced fibrosis compared to those with no/minimal fibrosis.

Conclusion: Reduced levels of the peripheral blood N/L ratio were found to give high sensitivity, speciﬁcity and predictive values in CHB patients with significant fibrosis. The prominent finding of our research suggests that the N/L ratio can be used as a novel noninvasive marker of fibrosis in patients with CHB.

Citing Articles

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Ruta V, Man A, Alexescu T, Motoc N, Tarmure S, Ungur R Medicina (Kaunas). 2020; 56(8).

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