Coilin: The First 25 Years

Overview

Journal RNA Biol

Specialty Molecular Biology

Date 2015 May 14

PMID 25970135

Citations 43

Authors

Martin Machyna

Karla M Neugebauer

David Stanek

Affiliations

Soon will be listed here.

Abstract

Initially identified as a marker of coiled bodies (now Cajal bodies or CBs), the protein coilin was discovered a quarter of century ago. Coilin is now known to scaffold the CB, but its structure and function are poorly understood. Nearly devoid of predicted structural motifs, coilin has numerous reported molecular interactions that must underlie its role in the formation and function of CBs. In this review, we summarize what we have learned in the past 25 years about coilin's structure, post-transcriptional modifications, and interactions with RNA and proteins. We show that genes with homology to human coilin are found in primitive metazoans and comment on differences among model organisms. Coilin's function in Cajal body formation and RNP metabolism will be discussed in the light of these developments.

Citing Articles

Coilin Affects the Prognosis of Hepatocellular Carcinoma Through Cell Cycle and Apoptosis.

Lu L, Zhou X, Zheng J, Li D J Hepatocell Carcinoma. 2025; 12:367-382.

PMID: 40008396 PMC: 11853879. DOI: 10.2147/JHC.S500119.

Identification of coilin interactors reveals coordinated control of Cajal body number and structure.

Arias Escayola D, Zhang C, Nischwitz E, Scharfen L, Dorner K, Straube K J Cell Biol. 2024; 224(2).

PMID: 39602297 PMC: 11602656. DOI: 10.1083/jcb.202305081.

Finding new roles of classic biomolecular condensates in the nucleus: Lessons from fission yeast.

Sugiyama T Cell Insight. 2024; 3(5):100194.

PMID: 39228923 PMC: 11369484. DOI: 10.1016/j.cellin.2024.100194.

SART3 reads methylarginine-marked glycine- and arginine-rich motifs.

Wang Y, Zhou J, He W, Fu R, Shi L, Dang N Cell Rep. 2024; 43(7):114459.

PMID: 38985674 PMC: 11370311. DOI: 10.1016/j.celrep.2024.114459.

The fission yeast ortholog of Coilin, Mug174, forms Cajal body-like nuclear condensates and is essential for cellular quiescence.

Deng X, Yao Q, Horvath A, Jiang Z, Zhao J, Fischer T Nucleic Acids Res. 2024; 52(15):9174-9192.

PMID: 38828770 PMC: 11347179. DOI: 10.1093/nar/gkae463.

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