Retinal Nerve Fiber Layer and Ganglion Cell Complex Thicknesses Measured with Spectral-domain Optical Coherence Tomography in Eyes with No Light Perception Due to Nonglaucomatous Optic Neuropathy

Overview

Journal Jpn J Ophthalmol

Specialty Ophthalmology

Date 2015 May 13

PMID 25963074

Citations 10

Authors

Atsuya Miki

Takao Endo

Takeshi Morimoto

Kenji Matsushita

Takashi Fujikado

Kohji Nishida

Affiliations

Soon will be listed here.

Abstract

Purpose: To measure retinal nerve fiber layer thickness (RNFLT) and ganglion cell complex thickness (GCCT) in eyes with no light perception due to nonglaucomatous optic neuropathy using spectral-domain optical coherence tomography.

Methods: Fourteen eyes of 14 patients (9 women, 5 men; mean age 56.0 ± 16.6 (standard deviation) years] with no light perception due to optic neuropathy were recruited to this retrospective study. Only clinically stable eyes were included. Eyes were imaged at least 6 months after the onset of the disease. Five patients lost light perception due to traumatic optic neuropathy, four patients had ischemic optic neuropathy, two patients had optic neuritis, two patients had compressive optic neuropathy, and one patient had optic nerve atrophy. Global and quadrant RNFLTs were measured with the Cirrus HD-optical coherence tomography (OCT) system; global and hemisphere GCCTs were measured by spectral-domain OCT (RTVue OCT system). Only reliable OCT images were used for further analysis.

Results: Reliable RNFL images were obtained in 12 eyes, and reliable GCC images were obtained in 11 eyes. Global, superior, temporal, inferior, and nasal RNFLT were 57.5 ± 6.7, 60.6 ± 7.6, 54.1 ± 11.2, 59.7 ± 9.5, and 55.6 ± 7.4 µm, respectively. Global, superior, and inferior GCC thicknesses were 68.8 ± 9.6, 70.7 ± 12.2, and 67.8 ± 8.8 µm, respectively.

Conclusions: A considerable proportion of RNFL and GCC remained in eyes with no light perception vision. Clinicians should take this into account when evaluating the severity of optic neuropathy from OCT-measured RNFLT and GCCT.

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References

Funaki S, Shirakashi M, Funaki H, Yaoeda K, Abe H . Relationship between age and the thickness of the retinal nerve fiber layer in normal subjects. Jpn J Ophthalmol. 1999; 43(3):180-5. DOI: 10.1016/s0021-5155(99)00015-5. View

Tan O, Chopra V, Lu A, Schuman J, Ishikawa H, Wollstein G . Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography. Ophthalmology. 2009; 116(12):2305-14.e1-2. PMC: 2787911. DOI: 10.1016/j.ophtha.2009.05.025. View

Da Pozzo S, Iacono P, Marchesan R, Minutola D, Ravalico G . The effect of ageing on retinal nerve fibre layer thickness: an evaluation by scanning laser polarimetry with variable corneal compensation. Acta Ophthalmol Scand. 2006; 84(3):375-9. DOI: 10.1111/j.1600-0420.2006.00655.x. View

Harwerth R, Wheat J, Fredette M, Anderson D . Linking structure and function in glaucoma. Prog Retin Eye Res. 2010; 29(4):249-71. PMC: 2878911. DOI: 10.1016/j.preteyeres.2010.02.001. View

van Velthoven M, Faber D, Verbraak F, van Leeuwen T, Smet M . Recent developments in optical coherence tomography for imaging the retina. Prog Retin Eye Res. 2006; 26(1):57-77. DOI: 10.1016/j.preteyeres.2006.10.002. View

Leung C, Yu M, Weinreb R, Ye C, Liu S, Lai G . Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a prospective analysis of age-related loss. Ophthalmology. 2012; 119(4):731-7. DOI: 10.1016/j.ophtha.2011.10.010. View

Alamouti B, Funk J . Retinal thickness decreases with age: an OCT study. Br J Ophthalmol. 2003; 87(7):899-901. PMC: 1771773. DOI: 10.1136/bjo.87.7.899. View

Seibold L, Mandava N, Kahook M . Comparison of retinal nerve fiber layer thickness in normal eyes using time-domain and spectral-domain optical coherence tomography. Am J Ophthalmol. 2010; 150(6):807-14. DOI: 10.1016/j.ajo.2010.06.024. View

Poinoosawmy D, Fontana L, Wu J, Fitzke F, Hitchings R . Variation of nerve fibre layer thickness measurements with age and ethnicity by scanning laser polarimetry. Br J Ophthalmol. 1997; 81(5):350-4. PMC: 1722182. DOI: 10.1136/bjo.81.5.350. View

10.

Pavlidis M, Stupp T, Naskar R, Cengiz C, Thanos S . Retinal ganglion cells resistant to advanced glaucoma: a postmortem study of human retinas with the carbocyanine dye DiI. Invest Ophthalmol Vis Sci. 2003; 44(12):5196-205. DOI: 10.1167/iovs.03-0614. View

11.

Danesh-Meyer H, Yap J, Frampton C, Savino P . Differentiation of compressive from glaucomatous optic neuropathy with spectral-domain optical coherence tomography. Ophthalmology. 2014; 121(8):1516-23. DOI: 10.1016/j.ophtha.2014.02.020. View

12.

Medeiros F, Zangwill L, Bowd C, Mansouri K, Weinreb R . The structure and function relationship in glaucoma: implications for detection of progression and measurement of rates of change. Invest Ophthalmol Vis Sci. 2012; 53(11):6939-46. PMC: 3466074. DOI: 10.1167/iovs.12-10345. View

13.

Balazsi A, Rootman J, Drance S, Schulzer M, Douglas G . The effect of age on the nerve fiber population of the human optic nerve. Am J Ophthalmol. 1984; 97(6):760-6. DOI: 10.1016/0002-9394(84)90509-9. View

14.

Leung C, Chong K, Chan W, Yiu C, Tso M, Woo J . Comparative study of retinal nerve fiber layer measurement by StratusOCT and GDx VCC, II: structure/function regression analysis in glaucoma. Invest Ophthalmol Vis Sci. 2005; 46(10):3702-11. DOI: 10.1167/iovs.05-0490. View

15.

Knight O, Chang R, Feuer W, Budenz D . Comparison of retinal nerve fiber layer measurements using time domain and spectral domain optical coherent tomography. Ophthalmology. 2009; 116(7):1271-7. PMC: 2713355. DOI: 10.1016/j.ophtha.2008.12.032. View

16.

Akashi A, Kanamori A, Nakamura M, Fujihara M, Yamada Y, Negi A . Comparative assessment for the ability of Cirrus, RTVue, and 3D-OCT to diagnose glaucoma. Invest Ophthalmol Vis Sci. 2013; 54(7):4478-84. DOI: 10.1167/iovs.12-11268. View

17.

Kiernan D, Mieler W, Hariprasad S . Spectral-domain optical coherence tomography: a comparison of modern high-resolution retinal imaging systems. Am J Ophthalmol. 2010; 149(1):18-31. DOI: 10.1016/j.ajo.2009.08.037. View

18.

Hood D, Anderson S, Rouleau J, Wenick A, Grover L, Behrens M . Retinal nerve fiber structure versus visual field function in patients with ischemic optic neuropathy. A test of a linear model. Ophthalmology. 2007; 115(5):904-10. PMC: 2987576. DOI: 10.1016/j.ophtha.2007.06.001. View

19.

Repka M, Quigley H . The effect of age on normal human optic nerve fiber number and diameter. Ophthalmology. 1989; 96(1):26-32. DOI: 10.1016/s0161-6420(89)32928-9. View

20.

Radius R, Anderson D . The histology of retinal nerve fiber layer bundles and bundle defects. Arch Ophthalmol. 1979; 97(5):948-50. DOI: 10.1001/archopht.1979.01020010506027. View