Calciphylaxis: Risk Factors, Diagnosis, and Treatment

Overview

Journal Am J Kidney Dis

Specialty Nephrology

Date 2015 May 12

PMID 25960299

Citations 138

Authors

Sagar U Nigwekar

Daniela Kroshinsky

Rosalynn M Nazarian

Jeremy Goverman

Rajeev Malhotra

Vicki Ann Jackson

Mihir M Kamdar

David J R Steele

Ravi I Thadhani

Affiliations

Soon will be listed here.

Abstract

Calciphylaxis is a rare but devastating condition that has continued to challenge the medical community since its early descriptions in the scientific literature many decades ago. It is predominantly seen in patients with chronic kidney failure treated with dialysis (uremic calciphylaxis) but is also described in patients with earlier stages of chronic kidney disease and with normal kidney function. In this review, we discuss the available medical literature regarding risk factors, diagnosis, and treatment of both uremic and nonuremic calciphylaxis. High-quality evidence for the evaluation and management of calciphylaxis is lacking at this time due to its rare incidence and poorly understood pathogenesis and the relative paucity of collaborative research efforts. We hereby provide a summary of recommendations developed by a multidisciplinary team for patients with calciphylaxis.

Citing Articles

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Successful Management of Calciphylaxis with Sodium Thiosulfate in End-Stage Renal Disease: A Case Report.

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