Calcific Uremic Arteriolopathy in Peritoneal Dialysis Populations

Overview

Journal Int J Nephrol

Publisher Wiley

Specialty Nephrology

Date 2011 Jul 13

PMID 21748002

Citations 13

Authors

Nicholas New

Janaki Mohandas

George T John

Sharad Ratanjee

Helen Healy

Leo Francis

Dwarakanathan Ranganathan

Affiliations

Soon will be listed here.

Abstract

Calciphylaxis or calcific uremic arteriolopathy is an infrequent complication of end stage kidney disease. It is characterized by arteriolar medial calcification, thrombotic cutaneous ischemia, tissue necrosis often leading to ulceration, secondary infection and increased mortality rates. Current, multimodality treatment involves local wound care, well-controlled calcium, phosphate and parathyroid hormone levels and combination therapy with sodium thiosulfate and hyperbaric oxygen therapy. This combination therapy may be changing the historically poor prognosis of calcific uremic arteriolopathy reported in the literature. Peritoneal dialysis is considered a risk factor based on limited publications, however this remains to be proven. Clinical presentation, diagnosis, pathogenesis and treatment of calcific uremic arteriolopathy in these patients are no different from other patients manifesting with this condition.

Citing Articles

Calcific Uremic Arteriolopathy (CUA) Among Malaysian Dialysis Patients: Clinical Characteristics, Treatment, and Outcomes.

Lee Y, Tan M, Bavanandan S, Bee B, Lim C, Mohd R Cureus. 2024; 16(11):e73711.

PMID: 39677159 PMC: 11646636. DOI: 10.7759/cureus.73711.

Sodium Thiosulfate for Calciphylaxis Treatment in Patients on Peritoneal Dialysis: A Systematic Review.

Gossett C, Suppadungsuk S, Krisanapan P, Tangpanithandee S, Thongprayoon C, Mao M Medicina (Kaunas). 2023; 59(7).

PMID: 37512116 PMC: 10386543. DOI: 10.3390/medicina59071306.

Success of small-dose fractionated sodium thiosulfate in the treatment of calciphylaxis in a peritoneal dialysis patient.

Lu Y, Shen L, Zhou L, Xu D BMC Nephrol. 2022; 23(1):4.

PMID: 34979980 PMC: 8722146. DOI: 10.1186/s12882-021-02648-9.

Successful Treatment of Calciphylaxis in a Young Female With End-Stage Renal Disease on Peritoneal Dialysis With Parathyroidectomy, Intensification of Dialysis, and Sodium Thiosulphate-A Case Report and Literature Review.

Roy S, Reddy S, Garcha A, Vantipalli P, Patel S, Rahman E J Investig Med High Impact Case Rep. 2021; 9:23247096211060580.

PMID: 34845938 PMC: 8637396. DOI: 10.1177/23247096211060580.

Penile calciphylaxis in a patient on combined peritoneal dialysis and hemodialysis.

Kasai T, Washida N, Muraoka H, Fujii K, Uchiyama K, Shinozuka K CEN Case Rep. 2018; 7(2):204-207.

PMID: 29594982 PMC: 6181884. DOI: 10.1007/s13730-018-0327-0.

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