Is the Scavenger Receptor MARCO a New Immune Checkpoint?

Overview

Journal Oncoimmunology

Specialty Allergy & Immunology

Date 2015 May 6

PMID 25941575

Citations 14

Authors

Mohamed S Arredouani

Affiliations

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Abstract

Whereas macrophages use the scavenger receptor MARCO primarily in antimicrobial immunity by interacting with both exogenous and endogenous environments, in dendritic cells (DCs) MARCO is believed to pleiotropically link innate to adaptive immunity. MARCO exerts a significant modulatory effect on TLR-induced DC activation, thus offering novel avenues in cancer immunotherapy.

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