Metabolic Regulation of a Bacterial Cell System with Emphasis on Escherichia Coli Metabolism

Overview

Journal ISRN Biochem

Specialty Biochemistry

Date 2015 May 5

PMID 25937963

Citations 43

Authors

Kazuyuki Shimizu

Affiliations

Soon will be listed here.

Abstract

It is quite important to understand the overall metabolic regulation mechanism of bacterial cells such as Escherichia coli from both science (such as biochemistry) and engineering (such as metabolic engineering) points of view. Here, an attempt was made to clarify the overall metabolic regulation mechanism by focusing on the roles of global regulators which detect the culture or growth condition and manipulate a set of metabolic pathways by modulating the related gene expressions. For this, it was considered how the cell responds to a variety of culture environments such as carbon (catabolite regulation), nitrogen, and phosphate limitations, as well as the effects of oxygen level, pH (acid shock), temperature (heat shock), and nutrient starvation.

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