Kinamycin Biosynthesis Employs a Conserved Pair of Oxidases for B-ring Contraction

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2015 Apr 30

PMID 25920893

Citations 17

Authors

Bin Wang

Jinwei Ren

Liyuan Li

Fang Guo

Guohui Pan

Guomin Ai

Bertrand Aigle

Keqiang Fan

Keqian Yang

Affiliations

Soon will be listed here.

Abstract

The biosynthesis of diazobenzofluorene kinamycins requires a hitherto uncharacterized B-ring contraction. Via detailed genetic and enzymatic analyses we unambiguously characterized the conserved pairs of oxidases, AlpJ and AlpK homologs, as nature's machinery for benzofluorenone formation, which paves the way for the investigation of the following diazo assembly.

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