Factors Controlling Nutrient Availability to the Developing Fetus in Ruminants

Overview

Journal J Anim Sci Biotechnol

Publisher Biomed Central

Date 2015 Apr 25

PMID 25908972

Citations 24

Authors

Kathrin A Dunlap

Jacob D Brown

Ashley B Keith

M Carey Satterfield

Affiliations

Soon will be listed here.

Abstract

Inadequate delivery of nutrients results in intrauterine growth restriction (IUGR), which is a leading cause of neonatal morbidity and mortality in livestock. In ruminants, inadequate nutrition during pregnancy is often prevalent due to frequent utilization of exensive forage based grazing systems, making them highly susceptible to changes in nutrient quality and availability. Delivery of nutrients to the fetus is dependent on a number of critical factors including placental growth and development, utero-placental blood flow, nutrient availability, and placental metabolism and transport capacity. Previous findings from our laboratory and others, highlight essential roles for amino acids and their metabolites in supporting normal fetal growth and development, as well as the critical role for amino acid transporters in nutrient delivery to the fetus. The focus of this review will be on the role of maternal nutrition on placental form and function as a regulator of fetal development in ruminants.

Citing Articles

Methionine supply during mid-gestation modulates the bovine placental mTOR pathway, nutrient transporters, and offspring birth weight in a sex-specific manner.

Gouvea V, Smithyman M, Hentz F, Bagheri N, Batistel F J Anim Sci. 2024; 102.

PMID: 39390894 PMC: 11537801. DOI: 10.1093/jas/skae305.

Effects of exposure to chronic ergot alkaloids on phenylephrine contractile response of maternal pedal artery, umbilical artery, and umbilical vein in pregnant ewes.

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Increasing the Understanding of Nutrient Transport Capacity of the Ovine Placentome.

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Timing of maternal nutrient restriction during mid- to late-gestation influences net umbilical uptake of glucose and amino acids in adolescent sheep.

Trotta R, Vasquez-Hidalgo M, Smith B, Reed S, Govoni K, Vonnahme K J Anim Sci. 2023; 101.

PMID: 37982730 PMC: 10684045. DOI: 10.1093/jas/skad383.

Allantoic fluid metabolome reveals specific metabolic signatures in chicken lines different for their muscle glycogen content.

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