Inflammatory Macrophages in Pancreatic Acinar Cell Metaplasia and Initiation of Pancreatic Cancer

Overview

Journal Oncoscience

Specialty Oncology

Date 2015 Apr 22

PMID 25897428

Citations 22

Authors

Geou-Yarh Liou

Peter Storz

Affiliations

Soon will be listed here.

Abstract

The roles of inflammatory macrophages in pancreatic tissue and the development of pancreatic cancer have not been well characterized. Recently it was shown that inflammatory macrophages, besides their function in clearing dead cells, also initiate pancreatic acinar cell metaplasia to duct-like progenitor cells. While in pancreatitis this is a reversible process, in context of an oncogenic stimulus this process is irreversible and can lead to the formation of precancerous lesions. Recent work now indicates that acquisition of an activating Kras mutation in acinar cells initiates signaling that leads to chemoattraction of M1-poliarized macrophages. This oncogene-caused chronic microinflammation can accelerate the pathogenesis of pancreatic cancers.

Citing Articles

Cytokine CCL9 Mediates Oncogenic KRAS-Induced Pancreatic Acinar-to-Ductal Metaplasia by Promoting Reactive Oxygen Species and Metalloproteinases.

Liou G, Byrd C, Storz P, Messex J Int J Mol Sci. 2024; 25(9).

PMID: 38731942 PMC: 11083758. DOI: 10.3390/ijms25094726.

Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment.

Amo-Aparicio J, Dominguez A, Atif S, Dinarello A, Azam T, Alula K Cancer Res Commun. 2023; 3(9):1899-1911.

PMID: 37772994 PMC: 10510589. DOI: 10.1158/2767-9764.CRC-23-0065.

Targeting in pancreatic adenocarcinoma: Progress in demystifying the holy grail.

Elhariri A, Alhaj A, Ahn D, Sonbol M, Bekaii-Saab T, Wu C World J Clin Oncol. 2023; 14(8):285-296.

PMID: 37700806 PMC: 10494558. DOI: 10.5306/wjco.v14.i8.285.

Roles of differently polarized macrophages in the initiation and progressionof pancreatic cancer.

Storz P Front Immunol. 2023; 14:1237711.

PMID: 37638028 PMC: 10450961. DOI: 10.3389/fimmu.2023.1237711.

Inflammatory and alternatively activated macrophages independently induce metaplasia but cooperatively drive pancreatic precancerous lesion growth.

Liou G, Fleming Martinez A, Doppler H, Bastea L, Storz P iScience. 2023; 26(6):106820.

PMID: 37250781 PMC: 10212997. DOI: 10.1016/j.isci.2023.106820.

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