Inflammatory Cytokine Signaling During Development of Pancreatic and Prostate Cancers

Overview

Journal J Immunol Res

Publisher Wiley

Specialty Allergy & Immunology

Date 2018 Jan 31

PMID 29379802

Citations 11

Authors

Geou-Yarh Liou

Affiliations

Soon will be listed here.

Abstract

Inflammation is essential for many diseases including cancer. Activation and recruitment of immune cells during inflammation result in a cytokine- and chemokine-enriched cell environment, which affects cancer development. Since each type of cancer has its unique tumor environment, effects of cytokines from different sources such as tumor-infiltrating immune cells, stromal cells, endothelial cells, and cancer cells on cancer development can be quite complex. In this review, how immune cells contribute to tumorigenesis of pancreatic and prostate cancers through their secreted cytokines is discussed. In addition, the cytokine signaling that tumor cells of pancreatic and prostate cancers utilize to benefit their own survival is delineated.

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