Galacto Configured N-aminoaziridines: a New Type of Irreversible Inhibitor of β-galactosidases

Overview

Journal Org Biomol Chem

Publisher Royal Society of Chemistry

Specialties Biochemistry
Chemistry

Date 2015 Apr 22

PMID 25895752

Citations 6

Authors

Anna Alcaide

Ana Trapero

Yolanda Perez

Amadeu Llebaria

Affiliations

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Abstract

A new type of galactose mimetics has been synthesized following a straightforward synthetic approach based on cyclohexene olefin aziridination reactions directed by hydroxyl substituents. These enantiomerically pure galacto-configured N-aminoaziridines are potent irreversible inhibitors of Aspergillus oryzae and Escherichia coliβ-galactosidases.

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