Mechanisms Involved in Breast Cancer Liver Metastasis

Overview

Journal J Transl Med

Publisher Biomed Central

Specialties Biomedical Engineering
General Medicine

Date 2015 Apr 18

PMID 25885919

Citations 65

Authors

Rui Ma

Yili Feng

Shuang Lin

Jiang Chen

Hui Lin

Xiao Liang

HeMing Zheng

Xiujun Cai

Affiliations

Soon will be listed here.

Abstract

Liver metastasis is a frequent occurrence in patients with breast cancer; however, the available treatments are limited and ineffective. While liver-specific homing of breast cancer cells is an important feature of metastasis, the formation of liver metastases is not random. Indeed, breast cancer cell factors contribute to the liver microenvironment. Major breakthroughs have been achieved recently in understanding breast cancer liver metastasis (BCLM). The process of liver metastasis consists of multiple steps and involves various factors from breast cancer cells and the liver microenvironment. A further understanding of the roles of breast cancer cells and the liver microenvironment is crucial to guide future work in clinical treatments. In this review we discuss the contribution of breast cancer cells and the liver microenvironment to liver metastasis, with the aim to improve therapeutic efficacy for patients with BCLM.

Citing Articles

Liver resection for breast cancer-related liver metastases: a case report.

Pangarsa E, Prabowo E, Subiyakto , Yudisaputro W, Istiadi H, Hadiyanto J J Med Case Rep. 2024; 18(1):635.

PMID: 39710686 PMC: 11665236. DOI: 10.1186/s13256-024-05001-4.

Molecular docking and / studies of a novel thiadiazole Schiff base as a hepatoprotective drug against angiogenesis induced by breast cancer.

Alqahtani N, Alfaifi M, Shati A A, Elbehairi S, Saleh A, Kotb E RSC Adv. 2024; 14(52):39027-39039.

PMID: 39659603 PMC: 11629753. DOI: 10.1039/d4ra06398h.

Male breast cancer metastasising to the liver: A case report.

Jiang M, Li L, Liu H, Xie H Oncol Lett. 2024; 28(5):530.

PMID: 39290955 PMC: 11406569. DOI: 10.3892/ol.2024.14663.

Concise review: breast cancer stems cells and their role in metastases.

Farahani M, Farjadmehr M, Atashi A, Momeni A, Behzadifard M Ann Med Surg (Lond). 2024; 86(9):5266-5275.

PMID: 39238997 PMC: 11374310. DOI: 10.1097/MS9.0000000000002270.

State of the Art Modelling of the Breast Cancer Metastatic Microenvironment: Where Are We?.

Nuckhir M, Withey D, Cabral S, Harrison H, Clarke R J Mammary Gland Biol Neoplasia. 2024; 29(1):14.

PMID: 39012440 PMC: 11252219. DOI: 10.1007/s10911-024-09567-z.

References

Erin N, Wang N, Xin P, Bui V, Weisz J, Barkan G . Altered gene expression in breast cancer liver metastases. Int J Cancer. 2009; 124(7):1503-16. DOI: 10.1002/ijc.24131. View

Eichbaum C, Meyer A, Wang N, Bischofs E, Steinborn A, Bruckner T . Breast cancer cell-derived cytokines, macrophages and cell adhesion: implications for metastasis. Anticancer Res. 2011; 31(10):3219-27. View

Spizzo G, Went P, Dirnhofer S, Obrist P, Simon R, Spichtin H . High Ep-CAM expression is associated with poor prognosis in node-positive breast cancer. Breast Cancer Res Treat. 2004; 86(3):207-13. DOI: 10.1023/B:BREA.0000036787.59816.01. View

Khatib A, Auguste P, Fallavollita L, Wang N, Samani A, Kontogiannea M . Characterization of the host proinflammatory response to tumor cells during the initial stages of liver metastasis. Am J Pathol. 2005; 167(3):749-59. PMC: 1698732. DOI: 10.1016/S0002-9440(10)62048-2. View

Grano M, Mori G, Minielli V, Colucci S, Vaira S, Giannelli G . HGF and M-CSF modulate adhesion of MDA-231 breast cancer cell by increasing osteopontin secretion. J Biol Regul Homeost Agents. 2002; 16(3):190-5. View

Palamakumbura A, Jeay S, Guo Y, Pischon N, Sommer P, Sonenshein G . The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells. J Biol Chem. 2004; 279(39):40593-600. DOI: 10.1074/jbc.M406639200. View

Herschkowitz J, Simin K, Weigman V, Mikaelian I, Usary J, Hu Z . Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol. 2007; 8(5):R76. PMC: 1929138. DOI: 10.1186/gb-2007-8-5-r76. View

Kagan H, Li W . Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. J Cell Biochem. 2003; 88(4):660-72. DOI: 10.1002/jcb.10413. View

Price J, Naito S, Fidler I . Growth in an organ microenvironment as a selective process in metastasis. Clin Exp Metastasis. 1988; 6(1):91-102. DOI: 10.1007/BF01580409. View

10.

Zhang Y, Ma B, Fan Q . Mechanisms of breast cancer bone metastasis. Cancer Lett. 2009; 292(1):1-7. DOI: 10.1016/j.canlet.2009.11.003. View

11.

Erler J, Bennewith K, Nicolau M, Dornhofer N, Kong C, Le Q . Lysyl oxidase is essential for hypoxia-induced metastasis. Nature. 2006; 440(7088):1222-6. DOI: 10.1038/nature04695. View

12.

Reichen J . The Role of the Sinusoidal Endothelium in Liver Function. News Physiol Sci. 2001; 14:117-121. DOI: 10.1152/physiologyonline.1999.14.3.117. View

13.

Hanahan D, Folkman J . Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 1996; 86(3):353-64. DOI: 10.1016/s0092-8674(00)80108-7. View

14.

Suva L, Griffin R, Makhoul I . Mechanisms of bone metastases of breast cancer. Endocr Relat Cancer. 2009; 16(3):703-13. PMC: 2914697. DOI: 10.1677/ERC-09-0012. View

15.

Hazan R, Kang L, Whooley B, Borgen P . N-cadherin promotes adhesion between invasive breast cancer cells and the stroma. Cell Adhes Commun. 1997; 4(6):399-411. DOI: 10.3109/15419069709004457. View

16.

Andre F, Cabioglu N, Assi H, Sabourin J, Delaloge S, Sahin A . Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancer. Ann Oncol. 2006; 17(6):945-51. DOI: 10.1093/annonc/mdl053. View

17.

Diamond J, Finlayson C, Borges V . Hepatic complications of breast cancer. Lancet Oncol. 2009; 10(6):615-21. DOI: 10.1016/S1470-2045(09)70029-4. View

18.

Polyak K, Weinberg R . Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer. 2009; 9(4):265-73. DOI: 10.1038/nrc2620. View

19.

Akhtari M, Mansuri J, Newman K, Guise T, Seth P . Biology of breast cancer bone metastasis. Cancer Biol Ther. 2007; 7(1):3-9. DOI: 10.4161/cbt.7.1.5163. View

20.

Thiery J, Acloque H, Huang R, Nieto M . Epithelial-mesenchymal transitions in development and disease. Cell. 2009; 139(5):871-90. DOI: 10.1016/j.cell.2009.11.007. View