Drug Sensitivity in Cancer Cell Lines is Not Tissue-specific

Overview

Journal Mol Cancer

Publisher Biomed Central

Specialties Molecular Biology
Oncology

Date 2015 Apr 17

PMID 25881072

Citations 17

Authors

Samira Jaeger

Miquel Duran-Frigola

Patrick Aloy

Affiliations

Soon will be listed here.

Abstract

Background: Cancer cell lines have a prominent role in the initial stages of drug discovery, facilitating high-throughput screening of potential drugs. However, their clinical relevance remains controversial.

Findings: We assess whether drug sensitivity in cancer cell lines is able to discriminate tissue specificity. We find that cancer-specific drugs do not show higher efficacies in cell lines representing the respective tissues. Even when considering distinct cancer subtypes and targeted therapies, most drugs are evenly effective/ineffective throughout all cell lines.

Conclusions: To get the most out of cell line panels, it will be necessary to look into their molecular characteristics, and integrate them into systems biology frameworks.

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