A New B7:CD28 Family Checkpoint Target for Cancer Immunotherapy: HHLA2

Overview

Journal Clin Cancer Res

Specialty Oncology

Date 2015 Apr 15

PMID 25869386

Citations 31

Authors

Yanping Xiao

Gordon J Freeman

Affiliations

Soon will be listed here.

Abstract

HHLA2 is a newly identified B7 family member that modulates T-cell functions through interaction with TMIGD2 and possibly a second receptor, with coinhibition in two studies and costimulation in one study. HHLA2 is expressed on a variety of human cancers, and its coinhibitory function makes it a candidate for cancer immunotherapy.

Citing Articles

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Comparison of mismatch repair and immune checkpoint protein profile with histopathological parameters in pancreatic, periampullary/ampullary, and choledochal adenocarcinomas.

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Increased co-expression of stromal HHLA2 and fibroblast activation protein in upper tract urothelial carcinoma.

Nishihara D, Kijima T, Arai K, Kamai T Int Urol Nephrol. 2023; 55(4):867-874.

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HHLA2 predicts improved prognosis of anti-PD-1/PD-L1 immunotherapy in patients with melanoma.

Huang F, Wu J, Cheng X, Wang J, Wen X, Li J Front Immunol. 2022; 13:902167.

PMID: 36003385 PMC: 9395140. DOI: 10.3389/fimmu.2022.902167.

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