Selective Cell Elimination in Vitro and in Vivo from Tissues and Tumors Using Antibodies Conjugated with a Near Infrared Phthalocyanine

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2015 Apr 14

PMID 25866624

Citations 28

Authors

Kazuhide Sato

Takahito Nakajima

Peter L Choyke

Hisataka Kobayashi

Affiliations

Soon will be listed here.

Abstract

Cell cultures and tissues often contain cellular subpopulations that potentially interfere with or contaminate other cells of interest. However, it is difficult to eliminate unwanted cells without damaging the very cell population one is seeking to protect, especially established tissue. Here, we report a method of eliminating a specific subpopulation of cells from a mixed 2D or 3D cell culture and a mixed-population tumor model by using antibody-photosensitizer conjugates (APC) with a near infrared (NIR) phthalocyanine-derivative (IRdye700DX, IR700) combined with NIR light exposure with minimal damage to non-targeted cells. Thus, APC combined with NIR light exposure holds promise as a method of removing specific cells from mixed cell cultures and tumors.

Citing Articles

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Sato K, Okada T, Okada R, Yasui H, Yamada M, Isobe Y ACS Nano. 2025; 19(8):8338-8356.

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Contrast-enhanced ultrasound imaging for monitoring the efficacy of near-infrared photoimmunotherapy.

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Near Infrared Photoimmunotherapy: A Review of Recent Progress and Their Target Molecules for Cancer Therapy.

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